Effect of high-frequency oscillation and percussion versus conventional ventilation in a piglet model of meconium aspiration

Pediatric Pulmonology
Laurent RenesmeEric Dumas De La Roque

Abstract

Meconium aspiration syndrome (MAS) remains a frequent cause of morbidity and mortality in term newborns. Our objective was to compare two modes of high-frequency ventilation, high-frequency oscillation (HFOV), and high-frequency percussive ventilation (HFPV) with conventional mechanical ventilation (CMV) in a piglet model of MAS. Fifteen newborn piglets were anesthetized, paralyzed, and intubated. Following the instillation of a 3 ml/kg solution of meconium diluted to 30%, the piglets were randomized to one of three groups: high-frequency oscillation (HFOV; Sensormedics®), HFPV (Percussionaire®), or CMV (Siemens®). Animals were ventilated for 6 hr to maintain arterial blood gases within a normal range, that is, pH 7.35-7.45, PaO(2) 10-16 kPa, PaCO(2) 4-6.6 kPa. Arterial blood gas measurements, dynCrs and dynRrs, ventilator settings, and vital signs (heart rate, arterial blood pressure, transcutaneous pulse oxygen saturation, and temperature) were collected at 30, 60, 90, 120, 180, 240, 300, and 360 min after meconium instillation. Oxygenation index (OI) ([(fraction of inspired oxygen)(mean airway pressure)(100)]/PaO(2) ), mean airway pressure, dynamic lung function, secretions cleared and histological alterations were studied i...Continue Reading

References

Nov 1, 1992·American Journal of Diseases of Children·T E WiswellW E Hachey
Jun 1, 1992·Pediatric Research·M S ParankaB B Stancombe
Aug 1, 1995·Journal of Paediatrics and Child Health·P N McDougallW W Butt
Jul 8, 1998·Pediatric Clinics of North America·G M Cleary, T E Wiswell
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·K J BarringtonN N Finer
Nov 25, 2000·Journal of Applied Physiology·J A AdamsM A Sackner
Mar 21, 2003·European Journal of Pediatrics·Patrick Van ReemptsJean-Claude Van der Auwera
Aug 21, 2003·Burns : Journal of the International Society for Burn Injuries·P ReperA Vanderkelen
May 12, 2004·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·P NolentS Renolleau
Mar 9, 2005·Critical Care Medicine·Ali Salim, Matthew Martin
Sep 9, 2005·Critical Care Medicine·Umberto LucangeloWalter A Zin
May 3, 2006·Pediatrics·Peter A DargavilleUNKNOWN Australian and New Zealand Neonatal Network
May 25, 2006·Current Opinion in Pediatrics·Howard B Panitch
Oct 4, 2006·Current Opinion in Anaesthesiology·D C Adams, J B Eisenkraft
Jul 10, 2008·Neonatology·Peter A DargavilleColin J Morley
Jan 23, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·B S SinghA R Spitzer
Jun 6, 2009·Pediatric Pulmonology·Stephen E MessierRobert K Gillette
Jun 23, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A Ribera CanoM C Lelong-Tissier
Oct 17, 2009·Early Human Development·Nestor E VainAdriana M Aguilar

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Citations

Dec 15, 2015·Pediatric Pulmonology·Nora HoferBernhard Resch
Sep 25, 2017·Physiological Research·D Mokra, A Calkovska

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