Effect of High-Intensity Focused Ultrasound on Drug Release from Doxorubicin-Loaded PEGylated Liposomes and Therapeutic Effect in Colorectal Cancer Murine Models

Ultrasound in Medicine & Biology
Hwan-Seok JeongHwan-Jeong Jeong

Abstract

The goal of the study described here was to evaluate the use of high-intensity focused ultrasound (HIFU) in drug release and its application in cancer therapy. HIFU was set to minimize hyperthermia, particularly non-specific hyperthermia, of exposed areas. An in vitro temperature-sensitive hydrogel phantom model determined the parameters of HIFU under mild condition settings (spatial average temporal average intensity [ISATA] = 83.35 W/cm(2)). PEGylated liposomal indocyanine green (LCLP-ICG) and PEGylated liposomal doxorubicin (LCLP-Dox) were prepared with the same mole ratio to allow direct comparison of drug release in vitro and in vivo. We induced drug release with HIFU treatment using LCLP-ICG coupled with optical imaging in vitro and in vivo. The size distribution changes in LCLP-ICG in vitro and fluorescence intensity changes in ICG after intra-tumoral injection of LCLP-ICG into CT26 solid tumors in vivo followed by HIFU confirmed the feasibility of the system. We validated the therapeutic effect of HIFU treatment of the CT26 mouse tumor model. The tumor growth rate was significantly reduced (p < 0.05) only in the group administered LCLP-Dox followed by cycles of HIFU treatment, and the chemotherapy of the CT26 solid tumo...Continue Reading

References

Mar 30, 1990·Biochimica Et Biophysica Acta·M B BallyL D Mayer
Jul 1, 1994·Scientific American·R K Jain
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J A Reddy, P S Low
Jul 18, 2002·Nature Reviews. Drug Discovery·David A LaVanRobert Langer
Sep 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sudaxshina Murdan
Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
Oct 9, 2004·Biochimica Et Biophysica Acta·Shao-Ling Huang, Robert C MacDonald
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Aug 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiao-Bing XiongQiang Zhang
Oct 6, 2006·Medicinal Research Reviews·Priya Prakash Karmali, Arabinda Chaudhuri
Jan 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alfia KhaibullinaChang H Paik
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Oct 30, 2010·Molecular Membrane Biology·Bo YuRobert J Lee
Jan 18, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tove J EvjenSigrid L Fossheim
Mar 13, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Feng-Yi YangMing-Cheng Wei

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Citations

Sep 5, 2018·Mini Reviews in Medicinal Chemistry·Julia B KrajewskaJakub Fichna
Aug 25, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhuoran WangWeiping Gao
Apr 4, 2021·Acta Biomaterialia·Rui SangWei Deng

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