Effect of high-intensity ultrasound-targeted microbubble destruction on perfusion and function of the rat heart assessed by pinhole-gated SPECT

Ultrasound in Medicine & Biology
Sophie HernotTony Lahoutte

Abstract

Although ultrasound-targeted microbubble destruction (UTMD) has been shown to induce bioeffects, UTMD is still desirable for therapeutic applications. Therefore, we studied the effects of UTMD on perfusion and function of the rat heart, assessed by (99m)Tc-MIBI pinhole-gated SPECT (Ph-gSPECT) compared with biomarker release and histopathology. Fifty-two male Wistar rats were studied. UTMD was performed using SonoVue, with a mechanical index of 1.0 or 1.6. Controls were treated without microbubbles or without ultrasound application. At baseline, day 1, day 7 and day 30, 35 rats were imaged with (99m)Tc-MIBI Ph-gSPECT to quantify left ventricular perfusion and function. In addition, troponin release and histopathology were investigated. No significant differences were observed for left ventricular ejection fractions, end-systolic and end-diastolic volumes, regional perfusion and functional scores up to 30 days after UTMD compared with controls. UTMD induced mild troponin release and early erythrocyte extravasation without necrosis, inflammation or fibrosis. Although UTMD has the potential to induce microlesions of the heart in small animals, these effects were transient without histological evidence of irreversible damage. Furthe...Continue Reading

References

Feb 1, 1990·Circulation·D K Glover, R D Okada
May 5, 1999·Lancet·K TachibanaK Tamura
Apr 5, 2002·The Journal of the Acoustical Society of America·Junru WuJen-Fu Chiu
Oct 3, 2002·Echocardiography·Shuyuan ChenPaul A Grayburn
Aug 10, 2004·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·T AlbrechtUNKNOWN EFSUMB Study Group
Sep 17, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Christian VanhovePhilippe R Franken
Nov 20, 2004·Ultrasound in Medicine & Biology·Annemieke van WamelNico de Jong
Jan 22, 2005·Echocardiography·Douglas L MillerWilliam F Armstrong
Mar 8, 2005·Ultrasound in Medicine & Biology·Ayache BouakazNico de Jong
Mar 31, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Nguyen TranPierre-Yves Marie
Oct 19, 2006·Ultrasound in Medicine & Biology·Joo Ha HwangLawrence A Crum
Apr 6, 2007·European Heart Journal·David VancraeynestJean-Louis J Vanoverschelde
Aug 7, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Guido GermanoDaniel S Berman
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexander L Klibanov
Dec 25, 2007·Journal of the American College of Cardiology·Michael L MainPaul A Grayburn
May 20, 2008·Advanced Drug Delivery Reviews·Sophie Hernot, Alexander L Klibanov
Nov 11, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sharon L MulvaghUNKNOWN American Society of Echocardiography
Dec 27, 2008·Ultrasound in Medicine & Biology·David VancraeynestJean-Louis Vanoverschelde

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Citations

May 11, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Monica SiepmannGeorg Schmitz
Aug 25, 2010·Investigative Radiology·Monica SiepmannGeorg Schmitz
Nov 4, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·An-Gaëlle CeulemansYvette Michotte

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