Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling

Pharmacology
Bilgen BasgutNihal Tümer

Abstract

The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by regulatory central mechanisms. Young (5 months) and old (27 months) male Fischer 344 × Brown Norway (F344/BN) rats were fed standard chow or 8% HS diet for 12 days. BP and heart rate (HR) were measured by telemetry. Mean arterial BP (MAP) was significantly elevated in old rats during the day and night when compared with young animals. The HS diet further elevated MAP in both age groups, and the increase was more pronounced in the old animals, while HR was not altered by age or HS diet. In addition, cardiovascular responses to restraint stress were diminished in the old when compared with the young and were unchanged with HS diet in either age group. Both age and the HS diet elevated the adrenomedullary mRNA levels of tyrosine hydroxylase, an indicator for sympathoexcitation. HS diet enhanced intracerebroventricular angiotensin II (AngII)-induced BP and HR elevations in both age groups. AngII type 1 receptor mRNA increased significantly in the hypothalamus with age and HS diet. Furthermore, hypothalamic p22phox mRNA and gp91phox protein, subunits of NADPH oxidase, as well as N...Continue Reading

References

Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·B Folkow
Oct 1, 1991·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·J S Turkkan, D S Goldstein
Jul 1, 1991·Hypertension·M H Weinberger, N S Fineberg
Aug 31, 1989·The New England Journal of Medicine·A P RocchiniM Martin
Nov 1, 1984·The Journal of Clinical Investigation·A Bellucci, B M Wilkes
May 1, 1982·Clinical and Experimental Pharmacology & Physiology·J MyersK Manley
Aug 1, 1997·Journal of Hypertension·H C DeterA M Sharma
Jan 1, 2004·American Journal of Hypertension·Mohamed A BayorhImad K Abukhalaf
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Lie GaoIrving H Zucker
Apr 9, 2005·Stroke; a Journal of Cerebral Circulation·Shokei Kim-MitsuyamaHiroshi Iwao
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher S Wilcox
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takashi AkasakiMitsuo Iida
Jul 25, 2008·Autonomic Neuroscience : Basic & Clinical·Yoshitaka Hirooka
Dec 23, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki KogaKenji Sunagawa

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