Effect of high-volume hemofiltration on mortality in critically ill patients: A PRISMA-compliant systematic review and meta-analysis

Medicine
Yusheng LuoYanling Li

Abstract

High-volume hemofiltration (HVHF) is widely used for blood purification in critically ill patients with systemic inflammatory syndromes. The purpose of this study was to evaluate the effect of HVHF on mortality at different follow-up periods in critically ill patients. We systematically searched PubMed, Embase, and the Cochrane Library through April 2017 to identify trials that evaluated the effect of HVHF on mortality in critically ill patients. Summary relative risks (RRs) and 95% confidence intervals (CIs) were employed to calculate the treatment effect using a random effects model. Eleven trials involving 1048 critically ill patients were included in this study. The summary results indicated no significant differences between HVHF and usual care for the incidence of 28-day mortality (RR: 0.93; 95%CI: 0.80-1.08; P = .321), 7-day mortality (RR: 0.72; 95%CI: 0.50-1.03; P = .072), 60-day mortality (RR: 1.00; 95%CI: 0.86-1.16; P = .997), and 90-day mortality (RR: 1.01; 95%CI: 0.88-1.16; P = .927). Subgroup analysis suggested HVHF significantly reduced the risk of 28-day mortality (RR: 0.64; 95%CI: 0.42-0.97; P = .035) if pooled the study sample size < 100. Our findings suggest HVHF significantly reduced the incidence of 28-day m...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·K P SteinbergL D Hudson
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 29, 1998·Critical Care Medicine·P E BollaertA Larcan
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Jul 12, 2002·Statistics in Medicine·Simon G Thompson, Julian P T Higgins
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Nov 12, 2005·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A E AdesJ P T Higgins
Apr 17, 2009·Critical Care : the Official Journal of the Critical Care Forum·Sergio VesconiUNKNOWN DOse REsponse Multicentre International collaborative Initiative (DO-RE-MI Study Group)
Sep 28, 2010·The International Journal of Artificial Organs·Zhang PengHuang Chen
Sep 6, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ping ZhangJianghua Chen
Feb 6, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·La-Ping ChuWen-Xia Dong
Dec 7, 2013·Current Opinion in Critical Care·Jesús VillarRobert M Kacmarek
Oct 8, 2014·Chest·Jeremy R BeitlerB Taylor Thompson
Apr 14, 2015·JAMA Internal Medicine·Christopher E Cox, Catherine L Hough
Apr 15, 2015·International Journal of Nursing Studies·Amanda J UllmanAlastair M Hull
May 16, 2015·Critical Care Medicine·Mark D Neuman, Roderic G Eckenhoff
Jul 15, 2015·American Journal of Respiratory and Critical Care Medicine·Alain CombesCharles-Edouard Luyt
Oct 4, 2015·Intensive Care Medicine·Jean-Pierre QuenotChristophe Adrie

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