Effect of high-volume systematic local infiltration analgesia in Caesarean section: a randomised, placebo-controlled trial

Acta Anaesthesiologica Scandinavica
K R LarsenH Kehlet

Abstract

Pain after Caesarean section is often treated with opioids with a risk of side effects. Wound infiltration with local anaesthetics is effective and has few side effects, but volume vs. dose concentration has not been examined. Ninety patients scheduled for elective Caesarean section included in a randomised, double-blinded, placebo-controlled trial receiving infiltration with 50 ml ropivacaine 0.5% or 125 ml ropivacaine 0.2% or 50 ml 0.9% saline (placebo) during surgery. Surgery was performed under lumbar spinal anaesthesia. Primary endpoint was post-operative pain. Secondary endpoints were rescue analgesic, post-operative nausea and vomiting, time spent in the postanesthesia care unit (PACU) and time to first mobilisation. No difference in pain response between groups, but time until maximum pain score was prolonged in the ropivacaine 0.5% group compared with the placebo group (P = 0.0493). The administration of ketobemidone at 24 h post-operatively in the ropivacaine 0.5% group was reduced compared with the placebo group (P = 0.020), and between the ropivacaine 0.2% group and the ropivacaine 0.5% group (P = 0.044). No significant differences between groups were found concerning time spent in the PACU, to first mobilisation or...Continue Reading

References

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Mar 1, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Ana-Marija HristovskaHenrik Kehlet
Jun 19, 2014·British Journal of Anaesthesia·L Ø Andersen, H Kehlet

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Citations

Jun 4, 2016·European Journal of Anaesthesiology·Oluwaseyi AdesopeAshraf S Habib
Dec 29, 2020·Anaesthesia·E RoofthooftUNKNOWN PROSPECT Working Group* of the European Society of Regional Anaesthesia and Pain Therapy and supported by the Obstetric Anae

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