Effect of hindlimb unloading and reloading on the soleus and plantaris muscles in diabetic rats

Journal of Physical Therapy Science
Sachiko MadokoroToshiaki Yamazaki

Abstract

[Purpose] This study aimed to induce disuse muscle atrophy in Goto-Kakizaki rats, a type 2 diabetes model, to investigate the effects of reloading on the soleus and plantaris muscles. [Materials and Methods] Wistar and Goto-Kakizaki (GK) rats were divided into 6 groups: Wistar Control (WC), GK Control (GC), Wistar Tail suspension (WS), GK Tail suspension (GS), and Wistar Reload (WR), GK Reload (GR). [Results] Investigation of myofiber cross-sectional area in Goto-Kakizaki rat soleus muscles indicated that the GS group showed significantly lower values than the GC and GR groups. No significant differences were observed between the GC and GR groups. However, investigation of plantaris muscles in Goto-Kakizaki rats indicated that the GS and GR groups showed a significant decrease compared to the GC group. No significant differences were found between the GS and GR groups. [Conclusion] Investigation of muscle weight/body weight ratios and myofiber cross-sectional area in tail suspension groups confirmed the induction of muscular atrophy. The differences in the degree of atrophy and recovery in terms of myofiber cross-sectional area observed in Goto-Kakizaki rat plantaris muscles may be influenced by the myofiber type and diabetes.

References

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Jan 25, 2000·The Anatomical Record·L J Wanek, M H Snow
Oct 16, 2001·American Journal of Physiology. Cell Physiology·P O Mitchell, G K Pavlath
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May 18, 2006·American Journal of Physiology. Endocrinology and Metabolism·Satoshi FujitaElena Volpi
May 21, 2013·International Journal of Epidemiology·Shiro TanakaUNKNOWN Japan Diabetes Complications Study Group
Jan 1, 2012·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Kazumi Zushi, Toshiaki Yamazaki

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Citations

Aug 28, 2019·NPJ Microgravity·Marie MortreuxSeward B Rutkove
Aug 3, 2021·Lipids in Health and Disease·Shoji TanakaToshiaki Yamazaki

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Software Mentioned

ImageJ
HydroGel
SPSS

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