Effect of histamine and stress on the gastric mucosal Ca2+ content during the development of gastric ulcers

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L L GrechishkinU Karnstedt

Abstract

The influence of histamine, its triazole derivative (3-beta-aminoethyl-1,2,4-triazole) and immobilization stress on the gastric mucosal Ca2+ content during the development of gastric ulcers in guinea pigs and rats was investigated. A considerable fall in the concentration of Ca2+ in gastric tissues of guinea pigs after administration of histamine 0.25 mg/kg, down to 80% (8.0 mumol/g), its derivative (1 mg/kg) to 72% (7.2 mucol/g) and stress to 76% (7.6 mumol/g) was recorded by atomic absorption-spectrophotometric techniques, while the calcium level in the controls stood at 9.9 mumole/g. Similar changes (90-65%) were seen in the blood plasma. In rats, the Ca2+-decreasing effects of stress ran closely parallel with increasing ulceration, and depended on the duration of stress. The immobilization of rats evoked a slight rise in the Na+ content of the gastric tissues. After 4 h immobilization, the tissue concentration of Na+ was increased to 116% of control levels. Cimetidine (100 mumol kg-1 more than 50% inhibited the development of gastric ulcers and prevented the change in Ca2+ concentration ions. Thus, the data suggest that Ca2+ ions take part not only in the regulation of secretion, but also in stress tissue dystrophy.

References

Aug 1, 1977·The American Journal of Digestive Diseases·B Simon, H Kather
Oct 1, 1976·Metabolism: Clinical and Experimental·E L KaplanB J Hill
Jan 1, 1973·The American Journal of Physiology·P R BieckR B Adkins
Feb 16, 1973·Nature·W DomschkeL Demling
Apr 1, 1968·The American Journal of Physiology·R J Levine, E C Senay
Jan 1, 1967·Medicina Et Pharmacologia Experimentalis. International Journal of Experimental Medicine·I S Zavodskaya, E V Moreva

Citations

Mar 17, 2018·Journal of Youth and Adolescence·Yuen Mi CheonTiffany Yip
Mar 20, 2018·Archives of Sexual Behavior·Joyce J EndendijkJudi Mesman
Jul 14, 2018·Journal of General Internal Medicine·Phyllis L CarrAmparo Villablanca
Feb 1, 1980·Journal of Youth and Adolescence·J Garbarino
Jun 1, 1980·Journal of Youth and Adolescence·E GreenbergerS McAuliffe
Apr 1, 1981·Journal of Youth and Adolescence·L D SteinbergL Garduque
Feb 1, 1988·Journal of Youth and Adolescence·P R Amato
Dec 1, 1989·Journal of Youth and Adolescence·R Larson, M H Richards
Jun 1, 1988·Journal of Autism and Developmental Disorders·S B Morgan
Jan 1, 1995·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·C B WangS S He

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