PMID: 7538965Mar 1, 1995Paper

Effect of histamine and substance P on the rabbit and human iris sphincter muscle

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
T YoshitomiS Ishikawa

Abstract

In an attempt to clarify the functional action of histamine and substance P on atropine-resistant miosis, we isolated rabbit and human iris sphincter muscles and investigated their mechanical properties using the isometric tension recording method. Substance P dose-dependently contracted the rabbit iris sphincter, but had no effect on the human iris sphincter. In the rabbit iris sphincter, histamine reduced the amplitude of twitch contraction evoked by field stimulation but had no effect on carbachol-induced contraction. Thioperamide, but not mepyramine or cimetidine, partially antagonized the histamine-induced reduction in the amplitude of twitch contractions. In the human iris sphincter, on the other hand, histamine dose-dependently provoked contraction and the amplitude of histamine-induced contraction was affected neither by atropine nor by indomethacin. These results provide evidence that histamine has strong contractile effect on the human iris sphincter muscle; the rabbit iris sphincter muscle, however, apparently lacks functional histamine receptors. In rabbits, exogenously applied histamine only activates H3 receptors located on the cholinergic nerve terminal, hence the excitatory neuro-effector transmission is suppres...Continue Reading

References

Jul 1, 1979·Acta Physiologica Scandinavica·A BillG Nilsson
Mar 1, 1977·Experimental Eye Research·K E Eakins, P Bhattacherjee
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Feb 1, 1983·The British Journal of Ophthalmology·H C Keulen-de VosJ T Jansen

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Citations

Jun 9, 2005·Experimental Eye Research·Kazutsuna YamajiShiro Usui
Jul 29, 2006·Brain Research Reviews·Josef TrogerEduard Schmid
Jan 22, 2003·Vision Research·Kazutsuna YamajiYoshitaka Ohnishi
Apr 7, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Cemal Çavdarli, Pınar Topcu Yilmaz

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