PMID: 42886Jul 1, 1979

Effect of histamine H2-receptor antagonists on concentration of noradrenaline, dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid in rat brain

Polish Journal of Pharmacology and Pharmacy
J Z Nowak, A Pilc


Intraventricular (ivt) administration of 50 micrograms of burimamide (BUR) or 250 micrograms of either metiamide (MET) or cimetidine (CIM) decreased noradrenaline (NA) concentration in the rat hypothalamus by nearly 30%. CIM did not significantly influence either dopamine (DA) or 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the striatum. Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) contents in the hypothalamus were not significantly affected by either MET or CIM.

Related Concepts

Histamine Measurement
Serotonin Measurement
Metiamide Monohydrochloride
Congenital Abnormal Synostosis
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt
Norepinephrine, (+, -)-Isomer

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