Effect of histamine H2-receptor stimulation on bombesin- and peptone-stimulated gastrin release in man

Digestive Diseases and Sciences
J H KleibeukerC B Lamers

Abstract

This study was undertaken to determine whether histamine H2-receptors are involved in the regulation of gastrin secretion in man. Since previous studies on the effect of histamine H2-receptor blockade on gastrin release are conflicting, we have studied the effect of histamine infusion (130 nmol/kg/hr) with simultaneous H1-receptor blockade on gastrin release in healthy male subjects. Intragastric pH was maintained at 4.5 by continuous intragastric titration during all studies. Histamine did not affect gastrin release stimulated by infusion of bombesin (90 pmol/kg/hr) or by a peptone meal. Integrated gastrin secretion during bombesin plus histamine was 767 +/- 151 pmol X min/liter (+/- SEM), compared to 757 +/- 144 pmol X min/liter during bombesin plus saline (not significant), whereas integrated meal-stimulated gastrin release was 1666 +/- 456 pmol X min/liter during histamine and 1856 +/- 492 pmol X min/liter during saline. It is concluded that histamine H2-receptors do not seem to be involved in the regulation of gastrin secretion in man.

References

Aug 21, 1975·The New England Journal of Medicine·R M HennR A Sturdevant
Jan 1, 1978·Digestion·R F LoganR C Heading
Jun 1, 1978·Agents and Actions·K MohriD Weber
Jul 1, 1985·Regulatory Peptides·J H KleibeukerJ H Walsh
Feb 21, 1970·British Medical Journal·M A Hassan, M Hobsley
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·V SchusdziarraE F Pfeiffer
Apr 1, 1984·Digestive Diseases and Sciences·V MaxwellJ H Walsh
May 1, 1984·The Journal of Clinical Investigation·V E EysseleinJ H Walsh
Mar 22, 2002·The Lancet Oncology·L C LawrieG I Murray
Aug 8, 1964·Lancet·J H LAWRIEA P FORREST

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Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·J H Kleibeuker, C B Lamers
Oct 1, 1992·Alimentary Pharmacology & Therapeutics·G M FullartonK E McColl

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