Effect of histamine on uterine vasculature in rats

European Journal of Pharmacology
C A Harvey, D A Owen


The effects of histamine infusions on the rat uterine vasculature have been studied using the radioactive microsphere technique. Histamine produced a marked uterine vasodilatation which could be partly mimicked by infusion of either the H1-receptor agonist, 2-(2-aminoethyl)pyridine, or the H2-receptor agonist, 4-methyl-histamine. Histamine-induced uterine vasodilatation could only be reduced significantly by administration of a combination of the H1- and H2-receptor antagonists mepyramine and metiamide but not by either antagonist given alone. It was concluded that histamine-induced vasodilatation in the rat uterus is mediated by both H1- and H2-receptors.


Apr 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·J R WoodsN S Assali
Sep 1, 1975·Journal of Medicinal Chemistry·G J DurantM E Parsons
Dec 1, 1976·The Journal of Endocrinology·C A Harvey, D A Owen
Apr 21, 1972·Nature·J W BlackE M Parsons
Apr 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·M C SHELESNYAK


Aug 1, 1979·European Journal of Pharmacology·J M Brandon, P J Raval
Jan 27, 1984·European Journal of Pharmacology·F AkarR K Türker

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