PMID: 6117941Jan 1, 1981Paper

Effect of histamine receptor blocking on human antibody-dependent cell-mediated cytotoxicity

Scandinavian Journal of Immunology
I LángG Petrányi


The effect of H1 and H2 receptor-blocking agents on antibody-dependent cell-mediated cytotoxicity (ADCC) was studied. The H1 receptor-blocker clemastinum and the H2 receptor blocker cimetidine dose-dependently inhibited the antibody-dependent cytotoxic activity of normal human peripheral blood mononuclear cells on chicken erythrocytes. The inhibition cannot be explained either by a direct toxic effect on effector cells or by blocking of Fc receptors. The possible involvement of histamine receptor-bearing effector cells in human ADCC is suggested.


Apr 1, 1975·The Journal of Clinical Investigation·M PlautC S Henney
Sep 1, 1978·Clinical Immunology and Immunopathology·W De CockH Verhaegen
Apr 5, 1974·Science·H R BourneG M Shearer
Jan 1, 1973·European Journal of Immunology·P Brain, R H Marston
Sep 1, 1970·Cellular Immunology·P Perlmann, H Perlmann

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Oct 1, 1982·Molecular Immunology·E Kownatzki
Sep 1, 1988·Annales De L'Institut Pasteur. Immunology·R Huchet, D Grandjon
Jan 1, 1988·Immunopharmacology and Immunotoxicology·G PéterY Kaneko
Aug 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·N HiraiK Osther

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