PMID: 602873Dec 1, 1977Paper

Effect of histidine on morphine-induced changes in brain histamine

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R W Henwood, I M Mazurkiewicz-Kwilecki

Abstract

Chronic morphine administration to rats resulted in a significant decrease in the hypothalamic and cerebro-cortical histamine concentrations. These low histamine values were restored to control levels when L-histidine was administered daily along with morphine treatment. Chronic treatment with L-histidine prevented the midbrain and cerebro-cortical histamine depletion in morphine-withdrawn rats, whereas in the hypothalamus the histamine level remained significantly decreased. The present data suggests that histamine may play a role in morphine dependence and withdrawal.

References

Mar 1, 1976·Clinical and Experimental Pharmacology & Physiology·J R Lee, M R Fennessy
Jan 1, 1975·Annual Review of Pharmacology·D H Clouet, K Iwatsubo
Aug 15, 1975·Life Sciences·J C Schwartz
Jan 1, 1978·Progress in Neuro-psychopharmacology·I M Mazurkiewicz-Kwilecki, B Bielkiewicz
Oct 1, 1976·Canadian Journal of Physiology and Pharmacology·B S Sastry, J W Phillis
Jul 1, 1975·Life Sciences·R W Henwood, I M Mazurikiewicz-Kwilecki
Aug 16, 1974·Brain Research·H L Haas
Jul 15, 1974·Experientia·P G Krüger
Feb 1, 1972·Journal of Neurochemistry·K M Taylor, S H Snyder
Mar 1, 1972·Journal of Neurochemistry·J C SchwartzC Rose
Jun 29, 1953·The Journal of Physiology·W FELDBERG, J TALESNIK

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Citations

Jun 26, 2007·Neuroscience Letters·Ying-xia GongZhong Chen
Dec 1, 1982·Medical Hypotheses·J C Newman
Dec 1, 1977·Environmental Health Perspectives·H S Posner, H L Falk

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