Effect of histochrome on brain vessels and research and exploratory activity of senescence-accelerated OXYS rats

Bulletin of Experimental Biology and Medicine
I G AgafonovaV A Stonik

Abstract

Changes in the diameter of brain vessels and intensity of collateral blood flow typical of chronic ischemia were detected by magnetic resonance imaging in senescence-accelerated OXYS rats demonstrating reduced (compared to Wistar rats) research and exploratory activity. Histochrome (antioxidant drug) produced positive effects on cerebral vessels in OXYS rats by stimulating collateral blood flow and acting as a vasodilator agent. Analysis of correlations showed that these effects of histochrome were closely related to its capacity to activate research and exploratory activity and reduce anxiety of OXYS rats in the open field test.

References

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Citations

Jun 11, 2009·Bulletin of Experimental Biology and Medicine·E Yu LeberfarbG M Dymshits
Oct 1, 2011·Advances in Gerontology = Uspekhi Gerontologii·V I RykovaN G Kolosova
Dec 10, 2015·Bulletin of Experimental Biology and Medicine·I G AgafonovaN G Kolosova
Nov 9, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marcelo S CostaLisiane O Porciúncula
Oct 25, 2011·Journal of Ethnopharmacology·Natalia A StefanovaNataliya G Kolosova
Jun 6, 2009·Bulletin of Experimental Biology and Medicine·A A ZhdankinaN G Kolosova
Aug 26, 2009·Bulletin of Experimental Biology and Medicine·A V Akhmadeev, L B Kalimullina
Sep 29, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natalia A StefanovaNataliya G Kolosova
Aug 10, 2019·Oxidative Medicine and Cellular Longevity·Natalia A StefanovaNataliya G Kolosova
Aug 27, 2021·Marine Drugs·Hyoung Kyu KimJin Han

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