Effect of histones from brain on DNA-synthesis in vitro

G JahnJ A Burdman


The results of these experiments demonstrate that histones from brain inhibit the replication of DNA in vitro. A similar effect is observed with polylysine or polyarginine. The reversion of inhibition by polyglutamic acid or acidic proteins is completed in all cases except when the DNA is previously complexed with histones, polyarginine or polylysine. This suggest that histones masking of DNA towards the polymerases involves electrostatic forces.


Jun 1, 1976·Journal of Neurochemistry·J A Burdman, I Szijan
Jun 28, 1974·Brain Research·I Szijan, J A Burdman
Jun 1, 1968·Biochemistry·W G WoodD J Holbrook
Sep 6, 1965·Biochimica Et Biophysica Acta·S Schwimmer, J Bonner


Related Concepts

Brain Chemistry
DNA Polymerase N3
DNA Replication
Histone H7
August Rats
Rats, Laboratory
In Vitro [Publication Type]

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