Effect of HIV-1 antiretroviral prophylaxis on hepatic and hematological parameters of African infants

AIDS
Taha E TahaRobin L Broadhead

Abstract

To measure hepatic and hematological parameters among neonates randomized to receive ultra-short antiretroviral regimens. As part of an on-going clinical trial in Malawi, infants born to women who received (early presenters) or did not receive (late presenters) standard intrapartum nevirapine (NVP) dosing were randomized to receive orally either single dose NVP alone or NVP plus zidovudine (twice daily for 1 week). An additional group of untreated infants (born to HIV-uninfected women) was enrolled as a control. Laboratory measurements were performed at birth and repeated at 6 weeks of age. Serum alanine aminotransferase (ALT) was measured on approximately 200 infants consecutively enrolled and randomized at the start of the trial. Complete blood count (CBC) was performed on approximately 800 infants at birth and 600 infants at 6 weeks of age. ALT and CBC were also determined on approximately 200 control infants. At birth there were no differences in ALT values between the groups of children. At 6 weeks of age, ALT levels were significantly higher among the treated groups compared with control group (geometric mean of 11.5 U/l for controls and 16.2-19.1 U/l for treated groups; P < 0.0001). Hematological parameters did not diffe...Continue Reading

References

Jul 1, 1985·Blut·A B Scott-EmuakporS I Ukpe
Aug 3, 1999·Clinical Pharmacology and Therapeutics·M MirochnickJ Connor
Mar 7, 2000·JAMA : the Journal of the American Medical Association·K M De CockN Shaffer

❮ Previous
Next ❯

Citations

Nov 7, 2007·The Pediatric Infectious Disease Journal·Marisa M Mussi-PinhataUNKNOWN NISDI Perinatal Protocol Study Group
Jul 1, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Irene R LubegaLaura Guay
Apr 10, 2014·Nigerian Journal of Clinical Practice·B U EzeonwuH U Okafor
Nov 1, 2005·Women's Health·Claire Thorne, Marie-Louise Newell
Dec 6, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Avinash K ShettyUNKNOWN HIVNET 023 Study Team
Jul 1, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jennifer WellsYvonne Maldonado
Mar 16, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cornelia Feiterna-SperlingMichael Obladen
Mar 30, 2005·Expert Opinion on Drug Safety·Claire Thorne, Marie-Louise Newell
Mar 9, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Claire Thorne, Marie-Louise Newell
Dec 10, 2014·Enfermedades infecciosas y microbiología clínica·Pablo IveliConcepció Figueras-Nadal
Aug 1, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Patrícia El Beitune, Geraldo Duarte
Apr 30, 2016·Infectious Diseases in Obstetrics and Gynecology·Christiana SmithElizabeth J McFarland
Jul 27, 2006·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Athena P KourtisUNKNOWN UNC Project BAN Study Team
Oct 16, 2004·Expert Review of Anti-infective Therapy·Marie-Louise Newell, Claire Thorne
Nov 24, 2005·Acta Paediatrica·Madeleine J BundersTaco W Kuijpers
Mar 23, 2021·Global Pediatric Health·Eren OyunguMegan S McHenry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.