Effect of HIV-1 Serostatus on the Prevalence of Asymptomatic Plasmodium falciparum Parasitemia Among Children Less Than 5 Years of Age in Benin City, Nigeria

Journal of the Pediatric Infectious Diseases Society
Ikechukwu R OkonkwoWilson E Sadoh

Abstract

Human immunodeficiency virus (HIV) infection and Plasmodium falciparum malaria are 2 of the gravest health threats in sub-Saharan Africa. Multiple repeat infections with the malaria parasite as seen in endemic areas are necessary to develop specific malaria immunity. HIV is an immunosuppressive virus and in children aged <5 years, development of malaria-specific immunity may be impaired and malaria parasite clearance in theory will be delayed; hence the predisposition to increased incidence of asymptomatic malaria or severe malaria. This cross-sectional study was carried out to examine associations between immunosuppression and asymptomatic malaria parasitemia (ASMP) in HIV-infected children aged <5 years in Benin City. One hundred seventy-nine asymptomatic HIV-1-positive and 179 age- and sex-matched HIV-1-negative children aged <5 years were recruited. The malaria parasite was determined by Giemsa-stained blood film by certified microscopy while concomitant CD4(+) count was estimated in the HIV-infected children. The prevalence of ASMP in those who were HIV-infected of 34.1% was significantly higher than 17.3% in the HIV uninfected (P = .001). The prevalence of ASMP was highest (59.3%) among subjects who were severely immunosu...Continue Reading

References

Oct 1, 1990·Annals of Tropical Medicine and Parasitology·L A SalakoO Walker
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·H M GillesJ Jewsbury
Mar 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·T E TahaP G Miotti
Dec 1, 1993·Annals of Tropical Medicine and Parasitology·C AtzoriM Scaglia
Jan 1, 1996·The American Journal of Tropical Medicine and Hygiene·R W SteketeeJ G Breman
Nov 5, 1997·The Pediatric Infectious Disease Journal·I KalyesubulaK Olness
May 29, 1998·International Journal of Epidemiology·D Chandramohan, B M Greenwood
Apr 15, 1999·Tropical Medicine & International Health : TM & IH·F H VerhoeffR L Broadhead
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·A FärnertV do Rosário
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·E Samba
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·J G BremanG T Keusch
Sep 13, 2002·The American Journal of Tropical Medicine and Hygiene·Joseph M Vinetz, Robert H Gilman
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michel A MissinouPeter G Kremsner
Sep 1, 1952·Annals of Tropical Medicine and Parasitology·L J BRUCE-CHWATT
Dec 3, 2003·Tropical Medicine & International Health : TM & IH·Eduardo VillamorWafaie W Fawzi
Dec 3, 2005·The Journal of Infectious Diseases·Moses R KamyaDiane Havlir
Dec 13, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jonathan MerminJohn P Ekwaru
Jun 28, 2011·The Lancet Infectious Diseases·Clara FlateauGilles Pialoux

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Apr 30, 2021·Frontiers in Cellular and Infection Microbiology·Ashleigh RoberdsV Ann Stewart

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