PMID: 9441587Jan 24, 1998Paper

Effect of HMGcoA reductase inhibitors on stroke. A meta-analysis of randomized, controlled trials

Annals of Internal Medicine
H C BucherG H Guyatt

Abstract

Stroke is a leading cause of death in the industrialized world, and hypercholesterolemia may be a risk factor for stroke. To determine whether reducing cholesterol levels with HMGcoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors or other antilipidemic interventions reduces risk for nonfatal and fatal stroke. A systematic search in the MEDLINE and EMBASE databases of the English-language and non-English-language literature published from 1966 through October 1996. All randomized, controlled trials of any cholesterol-lowering intervention that reported data on nonfatal and fatal strokes, on death from coronary heart disease, and on overall mortality were included. Whether treatment effects differed according to the type of cholesterol-lowering intervention used was investigated. Trials were reviewed for methods, inclusion and exclusion criteria, and outcomes. 28 trials (for a total of 49,477 study participants in the intervention group and 56,636 participants in the control group) were included. The risk ratio for nonfatal and fatal stroke with HMGcoA reductase inhibitors was 0.76 (95% CI, 0.62 to 0.92; test of heterogeneity, P > 0.2). The risk ratios for nonfatal and fatal stroke with fibrates, resins, and dietary...Continue Reading

Citations

Oct 1, 1998·Italian Journal of Neurological Sciences·P PratiI Pittaro
Jun 21, 2006·Journal of Thrombosis and Thrombolysis·Jessica L MegaEugene Braunwald
Jun 10, 2003·Current Atherosclerosis Reports·Cynthia A Sanoski
Jun 25, 2005·Current Atherosclerosis Reports·Hashem M ShaltoniDavid C Hess
Aug 27, 2002·Current Treatment Options in Cardiovascular Medicine·Jesse Weinberger
Mar 8, 2008·Current Treatment Options in Cardiovascular Medicine·Kumar Rajamani, Seemant Chaturvedi
Nov 30, 2000·Current Treatment Options in Neurology·S ChaturvediS R Levine
Jul 20, 2001·Archives of Gerontology and Geriatrics·M Dib
Jul 27, 2001·Neurologic Clinics·R Llinas, L R Caplan
Jul 10, 2002·Journal of the American College of Cardiology·Gavin J BlakeKaren M Kuntz
Mar 15, 2000·Journal of the American College of Cardiology·P A Tunick, I Kronzon
Jul 18, 2001·Journal of Diabetes and Its Complications·J A PapadakisD P Mikhailidis
Jan 6, 1999·Journal of Clinical Pharmacy and Therapeutics·R Y Henry, M J Kendall
Apr 17, 1999·The New England Journal of Medicine·L B Goldstein
Aug 12, 1999·The New England Journal of Medicine·R H Knopp
Aug 3, 2000·The New England Journal of Medicine·H D WhiteA M Tonkin
Dec 16, 2000·The New England Journal of Medicine·A S Brett
Sep 18, 1998·Current Opinion in Lipidology·N Qizilbash
Nov 13, 1998·Current Opinion in Lipidology·P S Bachorik
Feb 19, 2000·Current Opinion in Lipidology·J R Crouse
Feb 19, 2000·Current Opinion in Lipidology·J Davignon, R Laaksonen
Aug 17, 2000·Current Opinion in Lipidology·P R Jackson, L E Ramsay
Apr 23, 2003·Cardiology in Review·Jesse WeinbergerDawn Terashita
Dec 13, 2005·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Louis R Caplan, Norman R Hertzer
Jun 21, 2001·The American Journal of Geriatric Cardiology·D L DeSilvey
Aug 11, 2000·BMJ : British Medical Journal·J Tuomilehto
Dec 21, 2005·Heart·UNKNOWN British Cardiac SocietyUNKNOWN Stroke Association
Jun 23, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·J F AlbucherF Chollet
Mar 24, 2004·BMC Medicine·Sung Sug YoonAlison E Baird
Feb 27, 2007·Vascular Health and Risk Management·Jean Davignon, Lawrence A Leiter
Nov 27, 2002·Clinical and Experimental Hypertension : CHE·Giovanni Regesta
Jan 12, 2008·The American Journal of Medicine·Christopher O'ReganEdward J Mills
Sep 1, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Maged Y Z YoussefNabila A Abdella
May 1, 2004·Topics in Stroke Rehabilitation·MingMing Ning, Karen L Furie
Sep 6, 2011·Journal of Vascular Surgery·John J RicottaUNKNOWN Society for Vascular Surgery

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