Effect of hormonal contraception on the function of plasmacytoid dendritic cells and distribution of immune cell populations in the female reproductive tract

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Katherine G MichelZdenek Hel

Abstract

Epidemiological evidence suggests an association between the use of hormonal contraception and an increased risk of acquiring sexually transmitted diseases including HIV-1. We sought to elucidate the biological mechanisms underlying the effect of hormonal contraception on the immune system. Cross-sectional study. To delineate the biological mechanisms underlying the effect of hormonal contraceptives on the immune system, we analyzed the functional capacity of circulating plasmacytoid dendritic cells (pDCs), the distribution of vaginal immune cell populations, and the systemic and genital levels of immune mediators in women using depot medroxyprogesterone acetate (DMPA), NuvaRing, or combined oral contraceptives (COC). The use of DMPA or NuvaRing was associated with reduced capacity of circulating pDCs to produce interferon (IFN)-α and tumor necrosis (TNF-α) in response to TLR-9 stimulation. Systemic levels of IFN-α and cervicovaginal fluid levels of IFN-α, CXCL10, monocyte chemotactic protein-1, and granulocyte-colony stimulating factor were significantly lower in DMPA users compared to control volunteers not using hormonal contraception. The density of CD207 Langerhans cells in the vaginal epithelium was reduced in NuvaRing an...Continue Reading

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Citations

Apr 9, 2016·The Journal of Infectious Diseases·Kerry Murphy, Caroline M Mitchell
May 31, 2017·American Journal of Reproductive Immunology : AJRI·Sarah M DavisMark Phillippe
Jun 12, 2017·Contraception·Halley E M RileyJames N Kiarie
Sep 18, 2018·The Journal of Clinical Investigation·Irina A ZalenskayaGustavo F Doncel
Dec 27, 2018·AIDS Research and Human Retroviruses·Julie LajoieKeith R Fowke
Jan 9, 2018·Endocrine Reviews·Janet P HapgoodZdenek Hel
Nov 5, 2015·Current Opinion in Obstetrics & Gynecology·Lauren J RalphHeidi E Jones
Jul 9, 2016·Clinical Science·Morgane GriesbeckMarcus Altfeld
Aug 10, 2018·Evolution, Medicine, and Public Health·Alexandra AlvergneVedrana Högqvist Tabor
Sep 10, 2020·Journal of Cardiovascular Pharmacology·Vanessa Dela JustinaR Clinton Webb
Aug 30, 2018·Disease Models & Mechanisms·Jocelyn M WesselsCharu Kaushic
Nov 1, 2017·Frontiers in Immunology·Shuang LiJingtao Chen
Apr 19, 2019·AIDS Research and Human Retroviruses·Andrea ThurmanGustavo F Doncel
May 16, 2021·American Journal of Reproductive Immunology : AJRI·Hossaena AyeleAdam Burgener

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