PMID: 11915585Mar 28, 2002Paper

Effect of hormone replacement therapy on insulin secretion and insulin sensitivity in postmenopausal diabetic women

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
A M BorissovaDragomir Koev

Abstract

The aim of the present study was to evaluate the effect of three different combinations of hormone replacement therapy (HRT) on insulin secretion, peripheral insulin sensitivity, serum lipid levels and parameters of oxidative stress. Seven type II diabetic women of mean age 55.4 +/- 4.7 years, who had been menopausal for an average of 5 years, were enrolled in the study. Phases of insulin secretion--first (FPIS) and second (SPIS)--and the area under the curve (AUC) for insulin secretion were studied during an intravenous glucose tolerance test (IVGTT). Insulin sensitivity was determined using the manual euglycemic-hyperinsulinemic clamp technique. Three different HRT combinations were applied consecutively for 3-month periods: estradiol valerate plus cyproterone acetate (Climen); transdermal 17 beta-estradiol (System TTS 50) plus dydrogesterone (Duphaston) 10 mg daily for 10 days a month; oral 17 beta-estradiol plus dydrogesterone (Femoston) for 14 days a month. A group of nine women with normal glucose tolerance (according to World Health Organization criteria during a 75-g oral glucose tolerance test (OGTT)), of mean age 50.1 +/- 8.2 years and mean body mass index 24.60 +/- 2.01 kg/m2, were also studied, and served as a contr...Continue Reading

References

Oct 1, 1992·Diabetes Care·P J BingleyE A Gale
Apr 1, 1996·Maturitas·D W Cramer, H Xu

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Citations

Mar 1, 2008·Obesity Research & Clinical Practice·V Usha MenonHarish Kumar
Aug 25, 2005·Clinical Endocrinology·D KapoorT H Jones
Dec 2, 2017·Scientific Reports·Suwattanee KooptiwutPa-Thai Yenchitsomanus
Apr 21, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroaki KawanoHisao Ogawa
Apr 16, 2003·Molecular Pharmacology·Christian HonerChristoph Schumacher

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