PMID: 11907941Mar 23, 2002Paper

Effect of hormone replacement therapy on self-reported cognitive symptoms: results from the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial

Climacteric : the Journal of the International Menopause Society
B A ReboussinM A Espeland

Abstract

To describe self-reported cognitive changes in 875 postmenopausal women aged 45-64 years and assigned randomly to hormone therapy (either estrogen alone or estrogen in combination with a progestin). A 3-year placebo-controlled trial which included self-report data on problems with forgetfulness, concentration and distraction in groups of women assigned randomly to placebo, estrogen alone or estrogen plus one of three progestin regimens. Women assigned to any active treatment were consistently less likely to report cognitive symptoms than women assigned to placebo, but these results were not statistically significant. When compared with women assigned to estrogen plus any progestin, women assigned to estrogen alone had a significant increased risk for reporting problems with forgetfulness at follow-up (odds ratio, OR = 1.47). In the absence of problems with distraction at baseline, women assigned to estrogen alone were significantly less likely to report problems with distraction at follow-up, compared to women assigned to estrogen plus any progestin (OR = 0.36). Assignment to a continuous progestin regimen in combination with estrogen was marginally associated with an increased risk for reporting concentration problems at follo...Continue Reading

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Citations

Sep 23, 2003·Menopause : the Journal of the North American Menopause Society·Sally E ShaywitzBennett A Shaywitz
Oct 26, 1999·Journal of Endocrinological Investigation·M Dören
Jul 23, 2003·The Kaohsiung Journal of Medical Sciences·Chueh Chang, Catherine Hui-Wen Lin
Apr 20, 2006·Neurobiology of Aging·Lauren L HarburgerKaryn M Frick
Jun 5, 1998·Annual Review of Public Health·E Barrett-Connor, D Grady
Feb 18, 2011·European Journal of Clinical Pharmacology·Linda BrewerAlan Moore
Mar 13, 2019·International Journal of Language & Communication Disorders·Minna LaaksoJohanna Ruusuvuori
Jan 18, 2017·The Cochrane Database of Systematic Reviews·Jane MarjoribanksJasmine Lee
Oct 18, 2003·The Psychiatric Clinics of North America·Hadine JoffeLee S Cohen

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