Effect of HUK on the outcome of ruptured intracranial aneurysm

Brain and Behavior
Luyue ChenXinhua Tian

Abstract

To evaluate the clinical efficacy of Human Urinary Kallidinogenase (HUK) on the outcome of patients with ruptured intracranial aneurysm. This was a prospective, open-label study. At the Department of Neurosurgery in our hospital, 127 patients were treated and operated due to ruptured intracranial aneurysm in the period 2015-2016. After surgery, all the patients received basic treatment and 70 patients received additional HUK treatment (HUK group) according to their willing. In detail, 0.15 PNA unit of HUK injection plus 100 ml saline in intravenous infusion was performed, with once a day for 14 consecutive days. The modified Rankin Scale (mRS) scores and favorable mRS rates (mRS 0-1) were analyzed 3-month after the treatment. No difference was shown in the basic characteristics between the two groups (p > 0.05). Favorable mRS rate in the HUK group (71.43%) was significantly higher than that in control group (50.88%, p < 0.05). In addition, 3-month death rate was significantly lower in the HUK group. Delayed ischemic stroke rate was similar between the two groups. HUK can reduce morbidity and mortality of patients with ruptured intracranial aneurysm after surgery.

References

Oct 1, 1980·Neurology·L H PhillipsT M Sundt
Dec 1, 1993·Journal of Neurosurgery·G LanzinoW Alves
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·J W HopJ van Gijn
Feb 7, 2003·Current Pharmaceutical Design·Costanza Emanuelia, Paolo Madeddu
Jun 28, 2003·Stroke; a Journal of Cerebral Circulation·Seppo Juvela
Oct 29, 2003·Neurology·S M Dorhout MeesG J E Rinkel
Sep 24, 2005·Journal of Pharmacological Sciences·Marie Eve MoreauAlbert Adam
May 13, 2006·Stroke; a Journal of Cerebral Circulation·Seppo Juvela, Jari Siironen
Jul 20, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·H KoffijbergP Blomqvist
Jan 24, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Oliver A StonePaolo Madeddu
Jan 11, 2013·Neurology·Miikka KorjaJaakko Kaprio
Feb 15, 2013·Cerebrovascular Diseases·Thorsten SteinerUNKNOWN European Stroke Organization
Sep 4, 2015·Critical Care : the Official Journal of the Critical Care Forum·Hector LantiguaStephan A Mayer

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.