Effect of human chorionic gonadotropin on mammary gland differentiation and carcinogenesis

Carcinogenesis
I H RussoJ Russo

Abstract

The observation that mammary carcinogenesis is inhibited in rats which completed a pregnancy prior to exposure to the chemical carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) led us to determine whether the protective effect of pregnancy could be mimicked by treatment with the placental hormone chorionic gonadotropin (hCG). We also studied the effect of this treatment on mammary gland structure and differentiation, and determined whether hCG exerts toxic or collateral effects on body weight and endocrine organs. The systemic effect of hCG on body wt and endocrine organs and mammary gland was studied in outbred virgin Sprague-Dawley rats which at the age of 50 days started receiving 100 IU hCG i.p. daily for 21 days. The animals were subdivided into nine groups of five animals each; one group was killed on the first day of and the others at 5, 10, 15 and 21 days of injection and 5, 10, 15 and 21 days post injection. The effect of the hormonal treatment on the estrous cycle was determined by studying the vaginal smears taken during and after the injection period. The following parameters were determined: body wt, weight and morphology of pituitary gland, adrenals, ovaries and uterine horns. Mammary glands were processed for hist...Continue Reading

Citations

Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·J Russo, I H Russo
Jan 1, 1996·Journal of Mammary Gland Biology and Neoplasia·C Ip
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Kay-Uwe Wagner, Gilbert H Smith
Mar 23, 1995·Cancer Letters·J Russo, I H Russo
Aug 28, 2009·Molecular Human Reproduction·Nafis A Rahman, C V Rao
May 23, 1998·Annual Review of Pharmacology and Toxicology·S H Safe
Jun 24, 2003·Breast Cancer Research : BCR·Melanie R Ginger, Jeffrey M Rosen
Sep 1, 1996·Environmental Health Perspectives·I H Russo, J Russo
Apr 17, 2014·Breast Cancer Management·Julia Santucci-PereiraJose Russo
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L SivaramanB W O'Malley
Jan 1, 1994·In Vitro Cellular & Developmental Biology. Animal·M V AlvaradoI H Russo
Feb 14, 2009·Endocrine·Lakshmanaswamy RajkumarHuyen Duong
Aug 2, 2011·Journal of Mammary Gland Biology and Neoplasia·Irma H Russo, Jose Russo
Nov 24, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J Ph JanssensL Michiels
May 17, 2006·Journal of Carcinogenesis·Timothy WhitsettCoral A Lamartiniere
May 15, 2013·Experimental Cell Research·Holly A MartinsonPepper Schedin
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·P D Darbre
Aug 23, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Glendon M ZinserJoEllen Welsh
Oct 19, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Henning HvidHenrik E Jensen
Jul 9, 2004·Toxicology and Applied Pharmacology·Kimberly P MillerJodi A Flaws
Mar 28, 2007·Molecular and Cellular Endocrinology·Jaak Ph JanssensPeter Sieprath
May 20, 2014·Gynecologic Oncology·Giovanni SistiMassimiliano Fambrini
Jun 1, 2017·ACS Chemical Biology·Michael D RaineyCorrado Santocanale
Oct 8, 2011·International Journal of Immunopathology and Pharmacology·Manuela IezziF Cavallo
Mar 16, 2021·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Herman DepypereJose Russo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.