Effect of human dental bacterial plaque extract on the connective tissue of in-vitro cultured fetal rat calvaria

Archives of Oral Biology
H Larjava


Plaque extract (50 micrograms protein/ml) stimulated the synthesis of glycosaminoglycans (GAG) in cultured calvaria explants. The production of hyaluronic acid was increased (206-309 per cent) in the medium of bone explants cultured without fetal calf serum. In the presence of serum the synthesis of GAG was increased in control bones to the level of plaque-treated bones. The bone nitrogen content remained relatively unchanged, but dry weights, DNA and collagen contents were all decreased in plaque-treated bones. Bone resorption measured as 45Ca-release was enhanced in plaque-treated (173 +/- 18 per cent) and also parathormone-treated (155 +/- 10 per cent) bones. Serum in culture medium reduced the differences between treated and control bones by increasing the release of 45Ca from control bones. Plaque-induced bone resorption may be caused by increased cell secretion of GAG and inhibition of collagen synthesis or by increased collagen breakdown. Loss of mineral accompanies this modification of the organic substrate.


Oct 1, 1979·Journal of Oral Pathology·G J SeymourW I Davies
Apr 1, 1979·Journal of Periodontology·E Hausmann, L Ortman
Dec 10, 1974·Prostaglandins·L G Raisz, A R Koolemans-Beynen
May 1, 1972·Journal of Periodontology·J SchwartzR B Parker
Dec 1, 1973·Archives of Oral Biology·E Hausmann, N Weinfeld
May 1, 1967·Journal of Atherosclerosis Research·S ThunellS Gardell
Aug 1, 1981·Journal of Clinical Periodontology·W H van Palenstein Helderman
Mar 1, 1982·Calcified Tissue International·M ShlossmanR Dziak
Jul 1, 1980·Journal of Periodontal Research·W A SoskolneC Alander
Jan 1, 1980·Acta Odontologica Scandinavica·J TenovuoK Paunio
Oct 1, 1980·Journal of Biochemical and Biophysical Methods·M JalkanenM Tammi
Feb 1, 1964·Endocrinology·B FLANAGAN, S G NICHOL
May 1, 1974·Journal of Periodontology·Ernest Hausmann

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