PMID: 6990248Apr 1, 1980Paper

Effect of human gastric juice on the mutagenicity of chemicals

Mutation Research
S De Flora, V Boido

Abstract

10 mutagens were assayed in the Salmonella test after a pre-incubation step with human gastric juice. Such treatment affected the activity of 4 compounds, with different mechanisms, either in the sense of deactivation (sodium azide and sodium dichromate), of stabilization (captan), or even of potentiation (ICR-170). Conversely, the mutagenicity of other compounds (folpet, sodium nitrite, ICR-191, nitrofurantoin and a related drug) was unchanged. The stability of 2 carcinogens requiring metabolic activation, namely benzo[a]pyrene and aflatoxin B1, provided evidence that pre-incubation of compounds with gastric juice is compatible with the subsequent addition of liver post-mitochondrial preparations, thus reproducing in vitro 2 consecutive metabolic steps occurring in the organism. These findings lead us to report an improved correlation between assays in vivo and in vitro, in particular by explaining the lack of carcinogenicity of some mutagens introduced orally or by gastric intubation. Therefore, the Salmonella/gastric juice test is proposed as an additional assay for predicting the potential health hazards of chemicals.

References

Oct 1, 1978·Mutation Research·F L Petrilli, S De Flora
Nov 1, 1978·Mutation Research·F L Petrilli, S de Flora
Jul 1, 1979·Mutation Research·S de FloraC Bennicelli
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J McCann, B N Ames
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee

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Citations

Feb 1, 1988·Mutation Research·W M Owais, A Kleinhofs
Mar 1, 1990·Mutation Research·S De FloraP Zanacchi
Nov 1, 1987·Mutation Research·D LucaL Răileanu
Jan 1, 1982·Mutation Research·S de FloraC Bennicelli
Nov 1, 1987·Mutation Research·S De FloraV Savarino
Oct 1, 1980·Toxicology Letters·V BoidoS De Flora
Jun 12, 2012·Chemosphere·Deborah M ProctorSean M Hays
Jul 13, 2016·Toxicology and Applied Pharmacology·Silvio De FloraDeborah M Proctor
Mar 22, 2019·Critical Reviews in Toxicology·Mina SuhDeborah Proctor
Feb 21, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Carla Cedillo AlvarezAraceli Hernández Zavala

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