Effect of human immunodeficiency virus infection on S100A8/A9 inhibition of peripheral neutrophils oxidative metabolism.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Robert SchwartzHerve Y Sroussi

Abstract

Neutrophils are endowed with a highly active oxidative metabolism that is crucial for their antimicrobial functions but can produce oxidative conditions disruptive to the host. Opportunistic infections associated with HIV disease and ex vivo studies of neutrophils from HIV patients suggest that neutrophil dysfunctions significantly contribute to HIV disease. The calcium-binding proteins S100A8 and S100A9 are abundant cytosolic constituents of human neutrophils. Our previous work has shown that S100A8 and S100A9 inhibit neutrophil oxidative metabolism. In this study, we tested the hypothesis that neutrophils from HIV infected subjects respond differently to S100A8 and S100A9 when compared to neutrophils isolated from control HIV naive subjects. Neutrophils, freshly isolated from whole blood, were tested in a 96-well plate assay for their ability to oxidize the DCFH-DA probe. The neutrophils from HIV+ and HIV- subjects were stimulated with LPS and inhibited with recombinant S100A8 and S100A9. Our data indicate that when compared to neutrophils isolated from HIV- subjects, neutrophils from HIV+ subjects display an exaggerated response to LPS and a diminished response to S100A8 and S100A9 inhibition. Our data support our hypothesis...Continue Reading

References

Dec 1, 1990·AIDS Research and Human Retroviruses·S Legrand-PoelsJ Piette
Aug 1, 1984·The Journal of Infectious Diseases·F H ValoneE J Goetzl
Mar 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·M Mariano
Mar 1, 1995·American Journal of Surgery·J W EckertM L Brandt
Feb 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F MüllerM K Fagerhol
Dec 24, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·F StrasserC Ruef
Feb 3, 1998·Cellular and Molecular Life Sciences : CMLS·N Israël, M A Gougerot-Pocidalo
Oct 30, 1998·The Journal of Laboratory and Clinical Medicine·D L PitrakR C Allen
Feb 10, 1999·The Journal of Infectious Diseases·K C HayaniD L Pitrak
Mar 20, 1999·The Journal of Biological Chemistry·C A HarrisonC L Geczy
Feb 13, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·C ElbimM A Gougerot-Pocidalo
Mar 18, 2003·Molecular and Cellular Biology·Josie A R HobbsNancy Hogg
Aug 30, 2003·American Journal of Surgery·Gayle M Gordillo, Chandan K Sen
Sep 8, 2004·Experimental and Molecular Pathology·William E Stehbens
Jun 10, 2005·The FEBS Journal·Farid RahimiCarolyn L Geczy
Jun 15, 2006·Antioxidants & Redox Signaling·Alison C CaveAjay M Shah
Aug 26, 2006·Journal of Dental Research·H Y SroussiJ M Palefsky
Oct 3, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Masaki IkemotoMasatoshi Fujita
Dec 2, 2006·Journal of Leukocyte Biology·Herve Y SroussiJoel M Palefsky
Dec 28, 2007·Journal of Leukocyte Biology·György Haskó, Pál Pacher

❮ Previous
Next ❯

Citations

May 21, 2016·Frontiers in Immunology·Michelle A SugimotoMauro M Teixeira
Apr 12, 2019·Frontiers in Immunology·Kewreshini K NaidooChristina F Thobakgale
Oct 6, 2017·Archives of Virology·Mahmoud Mohammad YaseenBarakat Mohammad Shabsoug
Nov 24, 2011·Journal of Pediatric Gastroenterology and Nutrition·E HestvikL Grahnquist
May 25, 2021·Journal of Infection and Public Health·Maha Al-MozainiAyodele Alaiya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

© 2021 Meta ULC. All rights reserved