Effect of human immunodeficiency virus infection on the prevalence and incidence of vaginal intraepithelial neoplasia.

Obstetrics and Gynecology
L Stewart MassadHoward D Strickler

Abstract

To estimate the prevalence, incidence, and clearance of abnormal vaginal cytology and vaginal intraepithelial neoplasia (VAIN) in human immunodeficiency virus (HIV)-seropositive women. Pap tests were done semiannually for 335 HIV-seropositive and 75 HIV-seronegative women with prior hysterectomy in the prospective Women's Interagency HIV Study cohort. End points included abnormal Pap test results after hysterectomy and VAIN regardless of hysterectomy. Over a median of 5.6 years of follow-up, vaginal Pap test results were abnormal at 1,076 (29%; 95% confidence interval [CI] 25-33%) of 3,700 visits among HIV-seropositive compared with 31 (4%; 95% CI 2-8%) of 763 visits among HIV-seronegative women (P<.001). Abnormal Pap test results included 641 atypical squamous cells of undetermined significance, 425 low-grade squamous intraepithelial lesions, and 10 high-grade squamous intraepithelial lesions in HIV-seropositive women and 28 atypical squamous cells of undetermined significance and three low-grade squamous intraepithelial lesions in HIV-seronegative women. The incidence of abnormal Pap test results after hysterectomy was 14 per 100 person-years among HIV-seropositive and two per 100 person-years among HIV-seronegative women (P<...Continue Reading

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Citations

Jun 5, 2013·Obstetrics and Gynecology Clinics of North America·Minh Ly Nguyen, Lisa Flowers
Jun 9, 2016·Obstetrics and Gynecology·Stephanie SmeltzerJudy Levison
Aug 31, 2018·Journal of Lower Genital Tract Disease·Melissa BradburyCristina Centeno-Mediavilla
Jan 30, 2019·Interdisciplinary Perspectives on Infectious Diseases·Lunthita M DuthelyJoNell E Potter
May 7, 2021·American Journal of Obstetrics and Gynecology·L Stewart MassadHoward D Strickler

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