PMID: 7545035Mar 1, 1995Paper

Effect of human immunodeficiency virus infection on haematopoiesis

Baillière's Clinical Haematology
B R Davis, G Zauli

Abstract

The pathogenesis of peripheral blood cytopenias in AIDS patients is clearly multifactorial. Among the various contributing mechanisms, those involving a direct role of HIV-1 have been actively investigated in the past few years. It has now been convincingly demonstrated that HIV can impair the survival/proliferative capacity of purified haematopoietic progenitor cells. Although a subset of haematopoietic progenitor cells are perhaps susceptible to HIV-1 infection, both in vitro and in vivo, the suppressive effect does not require either active or latent infection and is probably mediated by the interaction of viral or virus-associated proteins with the cell membrane of haematopoietic progenitor cells. Both the viral load and the biological characteristics of the virus play an important role in suppression, since different isolates displayed different inhibitory activity. Haematosuppression is not a specific property of monocytotropic versus lymphocytotropic or low-replicating versus high-replicating isolates, and it will be important to exactly establish which viral component is crucial to suppression of haematopoietic progenitor cells. Since the haematopoietic stem cell is the common progenitor to both the myeloid and lymphoid...Continue Reading

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Citations

Aug 18, 2004·Molecular and Cellular Biology·Damian BrockschniederDieter Riethmacher
Dec 31, 1998·Annals of Diagnostic Pathology·M K KlassenA M Nelson
Mar 25, 2014·International Reviews of Immunology·Xin ShiPing Zhang
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Oct 27, 2020·Frontiers in Cellular and Infection Microbiology·Jacqueline María Valverde-VillegasJean-Pierre Molès

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