Effect of human interferons on morphological differentiation and suppression of N-myc gene expression in human neuroblastoma cells.

Japanese Journal of Cancer Research : Gann
H WatanabeJ Imanishi

Abstract

The activity of human interferons (HuIFNs) to induce morphological changes and the suppression of N-myc gene expression on human neuroblastoma cells (GOTO and KP-N-RT) was evaluated. Morphological differentiation, characterized as the extension and bifurcation of neurites, the formation of multinucleated giant cells and the formation of neurite networks, was induced by treatment with recombinant HuIFN-gamma (rHuIFN-gamma) and also with natural HuIFN-gamma on human neuroblastoma cells (GOTO and KP-N-RT). But recombinant HuIFN-alpha A and recombinant HuIFN-beta did not induce any changes. The rHuIFN-beta and rHuIFN-gamma inhibited the growth of GOTO and KP-N-RT cells more strongly than the rHuIFN-alpha A did. The expression of N-myc gene was suppressed in GOTO cells treated with rHuIFN-gamma. The suppressive effect of rHuIFN-gamma was dependent on the duration of the treatment. However, rHuIFN-alpha A and rHuIFN-beta did not suppress N-myc gene expression. Moreover, both morphological differentiation and the suppressive effect on N-myc gene expression by rHuIFN-gamma were inhibited in the presence of cycloheximide. These results suggest that the morphological changes and N-myc gene expression in neuroblastoma cells are closely re...Continue Reading

References

Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M EinatA Kimchi
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Citations

Oct 1, 1993·Molecular & General Genetics : MGG·C M McEnteeA P Hudson
Mar 19, 2013·Chemico-biological Interactions·Xuemei Liao, Kwok Nam Leung
Feb 1, 1994·Japanese Journal of Cancer Research : Gann·A ShikataL F Parada
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Apr 22, 1991·International Journal of Cancer. Journal International Du Cancer·L WuarinN Sidell
Feb 1, 1993·International Journal of Cancer. Journal International Du Cancer·W A PedersenH Yeger

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