PMID: 6397387Dec 1, 1984Paper

Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets

Diabetologia
C J Rhodes, K W Taylor

Abstract

Human islets of Langerhans were isolated from the pancreas removed from a 13-year-old female transplant donor. The islets were incubated in a culture medium for 24 h in the presence of human lymphoblastoid interferon (1000 units/ml). Insulin secretion, proinsulin biosynthesis, total protein biosynthesis and total insulin content were assessed at various concentrations of glucose in the presence of interferon. In interferon-treated islets glucose-stimulated insulin secretion was unaltered from that of control islets; however, glucose-stimulated proinsulin biosynthesis was specifically inhibited by interferon (48%, p less than 0.025). Total protein biosynthesis and total insulin content were not significantly affected by interferon.

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Citations

Jul 1, 1987·Molecular and Cellular Endocrinology·I L CampbellL C Harrison
Aug 16, 2003·Microbes and Infection·Malin Flodström-Tullberg
Mar 26, 2003·Cytokine & Growth Factor Reviews·Timothy A Stewart
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Jun 15, 2007·Virology·Monica HultcrantzMalin Flodström-Tullberg
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Mar 29, 2002·Nature Immunology·Malin FlodströmNora Sarvetnick
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Aug 18, 2018·Journal of Autoimmunity·Angela LombardiYaron Tomer

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