Effect of humic acids on lead poisoning in bones and on a subcellular level in mitochondria.

Environmental Science and Pollution Research International
Janka VaškováMarek Stupák

Abstract

Humic acids (HA) are natural substances which exhibit a remarkable spectrum of health benefits, such as their role in chelation. This study aims to supplement the current knowledge on the chelating effects of HA in chronic lead intoxication in rat femurs and in liver, heart and kidney mitochondria in an experiment lasting 10 weeks. Lead acetate trihydrate was administered to rats for 5 weeks at a daily dose of 155.5 mg/kg body weight. At the same time, rats were given three concentrations of HA, with their effect measured over the following 5 weeks. Increased Pb concentrations were detected in the femur after the first week, while HA-administered groups showed a tendency towards inhibiting the increase in Pb deposition. After 5 weeks, Pb concentrations dropped significantly in the HA groups. At the same time, however, other elements were redistributed, with a decrease in Se and Zn being particularly noteworthy. While an increase in Pb concentrations was found after 5 weeks of Pb administration, a concentration of 1% HA resulted in the least significant increase in Pb as well as an increase/decrease in Se/Cu, respectively. In mitochondria, an increase in Pb content was detected after the first and fifth weeks with concomitant re...Continue Reading

References

Aug 1, 1976·The Journal of Clinical Investigation·M B RabinowitzJ D Kopple
Nov 1, 1975·Postgraduate Medical Journal·D Barltrop, A M Smith
Nov 1, 1988·Archives of Environmental Health·L E WittmersA Alich
May 8, 2002·British Journal of Clinical Pharmacology·J N GordonP N Bennett
Jan 20, 2004·The Journal of Biological Chemistry·Paul A CobineDennis R Winge
Jul 11, 2006·Biochimica Et Biophysica Acta·Valeria Cizewski CulottaThomas V O'Halloran
Jul 15, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ana-Maria Florea, Dietrich Büsselberg
Dec 26, 2009·Mitochondrion·Erika Fernández-VizarraJosé Antonio Enríquez
Apr 14, 2011·In Vitro Cellular & Developmental Biology. Animal·Janka VaškováLadislav Vaško
Feb 13, 2014·Annals of the New York Academy of Sciences·Hans Zischka, Josef Lichtmannegger
Mar 4, 2015·Phytotherapy Research : PTR·Constance E J van Rensburg
Sep 19, 2015·Biological Trace Element Research·Yasir Furkan CaginC Colak
Jul 20, 2016·International Journal of Molecular Sciences·Lianmei HuZhaoxin Tang
Jun 1, 2015·Interdisciplinary Toxicology·Ab Latif WaniJawed Ahmad Usmani
Dec 3, 2016·Expert Review of Hematology·Bibbin T PaulSuzy V Torti
Dec 13, 2016·Metallomics : Integrated Biometal Science·S BlockhuysP Wittung-Stafshede
Mar 1, 2017·Acta Veterinaria Hungarica·József SzabóIstván Hullár
Mar 28, 2018·Acta Veterinaria Hungarica·István HullárJózsef Szabó
May 12, 2018·Biological Trace Element Research·Janka VaškováLadislav Vaško

❮ Previous
Next ❯

Citations

May 1, 2021·Animals : an Open Access Journal From MDPI·Marek HudákSlavomír Marcinčák

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.