PMID: 6165888Apr 1, 1981Paper

Effect of hycanthone on Schistosoma mansoni macromolecular synthesis in vitro

Molecular and Biochemical Parasitology
L P MattocciaD Cioli

Abstract

Adult, immature and hycanthone-resistant schistosomes were allowed to incorporate tritiated precursors of macromolecule synthesis in vitro, either in the presence of various concentrations of hycanthone, or at various times after removal of the drug. The effect on worms was compared to that on HeLa cells. The results show that hycanthone markedly inhibited the incorporation of uridine in all the systems studied, while the incorporation of thymidine and leucine was only secondarily affected. The inhibition of uridine incorporation reflected in part a decreased uptake of the radioactive precursor. The hycanthone-induced inhibition of uridine incorporation was essentially irreversible upon removal of the drug in adult schistosomes, while it was completely reversible in hycanthone-resistant worms, in immature worms and in HeLa cells. The effects of a hycanthone analog, IA-4, were largely comparable to the effects of the parent compound. These results suggest that the inhibition of RNA synthesis can be a possible explanation for the mechanism of the schistosomicidal action of hycanthone.

References

Aug 1, 1976·International Journal for Parasitology·D Cioli
Sep 8, 1972·Nature·J A Moore
Jul 18, 1967·Biochimica Et Biophysica Acta·I B WeinsteinE Hirschberg
Dec 4, 1965·Nature·D RosiS Archer
Jan 31, 1972·Biochimica Et Biophysica Acta·E H Harley, K R Rees
Feb 1, 1971·Experimental and Molecular Pathology·M WittnerR M Rosenbaum
Jun 4, 1971·Science·P E HartmanH Berger

❮ Previous
Next ❯

Citations

Nov 5, 2008·Archives of Pharmacal Research·M T Omar
Oct 8, 1985·European Journal of Pharmacology·K Enomoto, C Edwards
Feb 1, 1990·International Journal for Parasitology·M H el Kouni, F N Naguib
Dec 1, 1993·International Journal for Parasitology·H R AndersonW I Montgomery
Apr 1, 1995·International Journal for Parasitology·A W StittR O Mackender
Jul 15, 1985·Life Sciences·D CioliS Archer
May 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·L Pica-MattocciaS Archer
Jan 1, 1995·Pharmacology & Therapeutics·D CioliS Archer
Jun 1, 1984·Molecular and Biochemical Parasitology·M H IltzschM H El Kouni
May 1, 1993·Parasitology Today·D CioliS Archer
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y C DoongS S Wong
Dec 1, 1984·Parasitology·G C Coles

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.