PMID: 9449164Jan 1, 1997Paper

Effect of hydrocortisone, methylprednisolone aceponate and momethasone furoate on collagen synthesis in human skin in vivo

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
K M HaapasaariA Oikarinen

Abstract

Topical corticoids decrease de novo collagen synthesis in the human skin. We studied the effect of three corticoids, hydrocortisone (HC), methylprednisolone aceponate (MPA) and momethasone furoate (MMF) on the de novo synthesis of type I and III collagens. Fifteen healthy male volunteers treated four areas marked on their abdominal skin for 1 week. HC was applied twice a day, MPA and MMF once a day plus vehicle once a day and vehicle twice a day. After the treatment, suction blisters were induced on the treated areas, the suction blister fluid (SBF) was collected and procollagen propeptides of type I and III procollagens (PINP, PIIINP, respectively) were analyzed by radioimmunological assays. The protein concentration in SBF was determined by a colorimetric method. All the corticoids studied decreased the procollagen propeptide concentrations in SBF. HC decreased PINP concentration by 66%, MPA by 68% and MMF by 72%. HC decreased PIIINP by 62%, MPA by 68% and MMF by 72%. The protein concentration in SBF was decreased by 11-15% by these topical corticoids. HC decreases the concentration of procollagen propeptides in human skin in males to nearly the same extent as MPA and MMF.

Citations

Jan 8, 2013·Pediatric Surgery International·Paiboon SookpotaromPaisarn Vejchapipat
Dec 4, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·P NuutinenA Oikarinen
Jan 31, 2002·American Journal of Clinical Dermatology·Benedetta Brazzini, Nicola Pimpinelli
Jul 13, 2002·American Journal of Clinical Dermatology·Sakari ReitamoJohanna Saarikko
May 9, 2014·Expert Opinion on Pharmacotherapy·Sakari Reitamo, Anita Remitz
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Feb 6, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nadja Nicole ZöllerAugust Bernd
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Apr 20, 2004·Journal of Cellular Biochemistry·Kenneth R Cutroneo, Kenneth M Sterling
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Apr 12, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Laurent BarnesVictoria Rollason
Dec 22, 1998·Seminars in Cutaneous Medicine and Surgery·C Paul, V C Ho

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