Effect of Hydroethanolic Extract of Nigella sativa L. on Skin Wound Healing Process in Diabetic Male Rats

International Journal of Preventive Medicine
Elham NourbarHamid Nasri

Abstract

The aim of this study was to investigate the effect of hydroethanolic Nigella sativa L. extract on skin wound healing in diabetic male rats. This experimental study was conducted on 49 male Wistar rats weighing 220-250 g divided into 7 groups of 7 each: control (nondiabetic untreated), sham (nondiabetic eucerin-treated), nondiabetic phenytoin (1%)-treated, diabetic untreated, and three diabetic groups treated independently with phenytoin 1%, hydroethanolic N. sativa extracts 20% or 40%. Diabetes was induced with 60 mg/kg streptozosin in one administration. After anesthesia, 2 × 1 cm2 wounds were made on the rats' backs and each group was administered with its own respective treatment until the wounds were healed completely. Tissue specimens were prepared for histological examinations. The areas of the wounds were measured every 3 days. The data were analyzed by ANOVA and Tukey's post-hoc test. The mean duration of wound healing was 27 and 24 days for diabetic untreated and diabetic phenytoin-treated groups, respectively. Wounds were healed completely in nondiabetic untreated, sham, and nondiabetic phenytoin-treated groups on days 23, 24, and 21, respectively. The shortest duration of wound healing was seen in diabetic N. sativa...Continue Reading

References

Aug 5, 2000·Phytotherapy Research : PTR·M Burits, F Bucar
May 12, 2010·International Journal of Food Microbiology·Kavitha Palaniappan, Richard A Holley
Sep 24, 2015·Journal of Food Science and Technology·Mohamed F R HassanienHesham Farouk Oraby

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Citations

Dec 5, 2020·Pakistan Journal of Biological Sciences : PJBS·Bushra Abdulkarim MoharramAbdullah A H Dhabali
Apr 27, 2021·International Journal of Dermatology·Jacqueline R HwangAmor Khachemoune
Aug 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omid YazarluMaede Hasanpour

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