PMID: 3746165Aug 1, 1986Paper

Effect of hydrogen ion concentration on aldosterone secretion by isolated perfused canine adrenal glands

The Journal of Endocrinology
K J RadkeE G Schneider

Abstract

The direct effects of changes in extracellular hydrogen ion (H+) concentration on aldosterone secretion under basal, angiotensin II- and potassium-stimulated conditions were studied in isolated, perfused canine adrenal glands. Changes in extracellular H+ concentration were induced by altering either the partial pressure of CO2 (pCO2) or the HCO3- concentration of the perfusate. Acid-base disturbances had a more pronounced effect on aldosterone secretion under stimulated than under basal conditions. Increasing H+ concentration enhanced angiotensin II- and potassium-stimulated aldosterone secretion, whereas decreasing H+ concentration markedly inhibited the secretory response to these stimuli. Because changes in H+ concentration, whether produced by varying extracellular pCO2 or extracellular HCO3- concentration, had similar effects on angiotensin II-stimulated aldosterone secretion, the data suggest that H+ concentration per se is the important determinant of the aldosterone secretory rate. Interestingly, during the immediate recovery period from pCO2-induced alkalosis under both angiotensin II- and potassium-stimulated conditions, aldosterone secretion always returned to a value significantly higher than that obtained just befo...Continue Reading

Citations

Jul 1, 1989·Acta Physiologica Scandinavica·O Augustinsson, A Forslid
Dec 21, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Donald E WessonJan Simoni
Sep 29, 2017·Transactions of the Royal Society of Tropical Medicine and Hygiene·Thomas Butler
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Dominique M BoveeEwout J Hoorn
Jan 29, 2011·American Journal of Physiology. Renal Physiology·Donald E WessonSimon Sheather
Feb 11, 1988·The American Journal of Physiology·T A KotchenC E Ott
Jan 1, 1992·The American Journal of Physiology·R M ShepherdS J Quinn
Oct 2, 1987·Biochimica Et Biophysica Acta·S NirH B Pollard

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