PMID: 12787645Jun 6, 2003Paper

Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps

International Journal of Pharmaceutics
D PrabakaranSuresh P Vyas

Abstract

Diltiazem hydrochloride (DLTZ) is a freely water-soluble drug, because of its higher aqueous solubility, the suitability of the drug with elementary osmotic pumps is restricted. Plain DLTZ elementary osmotic pump had shown higher release rate. Drug entrapment in polymer matrix or addition of release retardant materials (various polymers) can reduce the release rate of drug. In present study, effect of appropriate hydrophilic polymers (HP) on the release pattern was investigated. Ingredients of the system were optimized for parameters like drug:polymer ratio and amount of osmogent, for the desired release pattern. Two optimized formulations were selected for further characterization. Theoretical release rate of the formulations were also determined and compared. Different dissolution models were applied to drug release data in order to establish release mechanism and kinetics. Criteria for selecting the most appropriate model were based on best goodness of fit and smallest sum of squared residuals.

References

Dec 1, 1975·Journal of Pharmaceutical Sciences·F Theeuwes
Mar 1, 1983·Journal of Pharmaceutical Sciences·F TheeuwesK C Kwan

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Citations

Feb 26, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·D PrabakaranSuresh P Vyas
Feb 5, 2013·Journal of Advanced Pharmaceutical Technology & Research·Sadhana R ShahiShivram B Shinde
Dec 8, 2004·Pharmaceutical Development and Technology·D PrabakaranSuresh P Vyas
May 1, 2010·Pharmaceutical Development and Technology·Xiongkai ChengGuangxi Zhai
Nov 26, 2009·Drug Development and Industrial Pharmacy·Rabiu YakubuYvonne T F Tan
Jan 25, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anil ChaudharyRanjit Singh
Jul 16, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vincent MalaterreRobert Gurny
Oct 5, 2012·Pharmaceutical Development and Technology·Wasim ShaikhSanjay B Bari
Sep 11, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Amal Ali ElkordyEbtessam Ahmed Essa
Jan 7, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Sally A El-ZahabyAmal H El-Kamel
Aug 27, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Li WuJiwen Zhang
Jul 10, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Javad ShokriAli Nokhodchi
May 19, 2017·The American Journal of Chinese Medicine·Sun Haeng ParkHo Kyoung Kim

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