Effect of hydrophobic mismatch on phase behavior of lipid membranes

Biophysical Journal
Elizabeth J WallacePeter D Olmsted

Abstract

We investigate the competing effects of hydrophobic mismatch and chain stretching on the morphology and evolution of domains in lipid membranes via Monte Carlo techniques. We model the membrane as a binary mixture of particles that differ in their preferred lengths, with the shorter particles mimicking unsaturated nonraft lipids and the longer particles mimicking saturated raft lipids. We find that phase separation can be induced upon increasing either the ratio J/kappa of the hydrophobic surface tension J to the compressibility modulus kappa. J/kappa determines the decay length for thickness changes. When this decay length is larger than the system size the membrane remains mixed. Furthermore, increasing the thickness relaxation time can induce transient phase separation.

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Citations

Dec 22, 2009·Current Opinion in Cell Biology·Jian LiuDavid G Drubin
Feb 19, 2016·The Journal of Physical Chemistry. B·Joan V BleeckerSarah L Keller
May 19, 2012·Molecular Membrane Biology·Nikola S MuellerFelix Spira
Apr 23, 2015·Biophysical Journal·John J Williamson, Peter D Olmsted
Sep 4, 2007·Biophysical Journal·Alexander J WagnerSylvio May
Jan 10, 2012·Biophysical Journal·Laura PicasSimon Scheuring
Jul 28, 2016·Biophysical Journal·Lorena Redondo-MorataSimon Scheuring
Aug 31, 2016·Journal of the American Chemical Society·Philip W FowlerPeter D Olmsted
Sep 29, 2015·Soft Matter·J J Williamson, P D Olmsted
Sep 13, 2007·The Journal of Biological Chemistry·Ana J García-SáezPetra Schwille
Dec 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J J Williamson, P D Olmsted
Jan 21, 2021·Physical Review. E·Ahis ShresthaChristoph A Haselwandter

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