Effect of hydroxyapatite fillers on the mechanical properties and osteogenesis capacity of bio-based polyurethane composite scaffolds

Journal of the Mechanical Behavior of Biomedical Materials
Jingjing DuYubao Li

Abstract

A newly designed hydroxyapatite-polyurethane (HA-PU) composite scaffold was prepared by polymerizing glyceride of castor oil (GCO) with isophorone diisocyanate (IPDI) and HA as fillers. The aim of this study was to determine the effect of HA fillers on the mechanical properties and osteogenesis capacity of the composite scaffolds. The physical and biological properties of the scaffold were evaluated by SEM observation, mechanical testing, cell culture and animal experiments. The results showed that HA fillers enhanced the mechanical properties of PU composite scaffolds such as compressive strength and elastic modulus. The mechanical properties of the scaffolds were seen to increase with increase in HA loading. The compressive strength of composite scaffold with 0 wt%, 20 wt%, 40 wt% of HA was 0.6 ± 0.1 MPa, 2.1 ± 0.1 MPa, and 4.6 ± 0.3 MPa, respectively. In vitro biodegradation studies of scaffolds were carried out. The results showed that all of the scaffolds were susceptible to cholesterol esterase (CE) -catalyzed degradation. HA-PU composite scaffolds exhibited a high affinity to osteoblastic cells and were good template for cell growth and proliferation. When implanted in bone defects of rats, PU scaffolds incorporated HA w...Continue Reading

Citations

Jan 24, 2020·Journal of Biomaterials Science. Polymer Edition·Mengjie XuDi Huang
Jul 28, 2020·Frontiers in Bioengineering and Biotechnology·Nicola Contessi NegriniLina Altomare
Aug 21, 2021·Biomedical Materials·Isnayra Kerolaynne Carneiro PachecoAna Cristina Vasconcelos Fialho

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