Effect of hydroxyethyl starch on vascular leak syndrome and neutrophil accumulation during hypoxia

Critical Care Medicine
Hans-Jürgen DieterichHolger K Eltzschig

Abstract

Several studies have suggested that intravenous hydroxyethyl starch treatment may dampen acute inflammatory responses. It is well documented that limited oxygen delivery to tissues (hypoxia) is common in acute inflammation, and numerous parallels exist between acute responses to hypoxia and to inflammation, including the observation that both are associated with increased vascular leakage and neutrophil infiltration of tissues. Therefore, we compared functional influences of hydroxyethyl starch on normoxic or posthypoxic endothelia. Laboratory study. University hospital. Cultured human microvascular endothelial cells and mice (C57BL/6/129 svj). We measured functional influences of hydroxyethyl starch on normoxic or posthypoxic endothelia. Studies to assess endothelial barrier function in vitro indicated that the addition of hydroxyethyl starch promotes endothelial barrier in a dose-dependent fashion and hydroxyethyl starch-barrier effects are increased following endothelial hypoxia exposure (human microvascular endothelial cells, 48 hrs, 2% oxygen). Treatment of human microvascular endothelial cells with hydroxyethyl starch resulted in a dose-dependent increase in 157-phosphorylated vasodilator-stimulated phosphoprotein, a prot...Continue Reading

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