PMID: 8961992Dec 14, 1996Paper

Effect of hydroxyethylstarch in brain-dead kidney donors on renal function in kidney-transplant recipients

Lancet
M L CittanovaP Coriat

Abstract

Hydroxyethylstarch used as a plasma-volume expander in brain-dead kidney donors has been suggested to induce osmotic-nephrosis-like lesions. We have studied its effect on kidney-transplant function. 52 patients who had received hydroxyethylstarch of iodinated contrast-media before brain death were excluded. 69 other brain-dead patients were prospectively included over 18 months and randomised into two groups. In the hydroxyethylstarch-gelatin group, patients received hydroxyethylstarch up to 33 mL/kg for colloid plasma-volume expansion, and afterwards received modified fluid gelatin. In the gelatin-only group, patients received only modified fluid gelatin as colloid plasma-volume expander. Multiple organs were procured in 29 cases, which included the kidneys in 27 cases (hydroxyethylstarch-gelatin 15, gelatin-only 12). There were no significant differences in the characteristics of patients between the two groups of kidney donors or of recipients (except for a small imbalance in sex in the recipients). During the first 8 days after transplantation, nine of 27 (33%) patients required extrarenal haemodialysis or haemodiafiltration in the hydroxyethylstarch-gelatin group compared with one of 20 (5%) in the gelatin-only group (p = ...Continue Reading

References

May 19, 1979·British Medical Journal·A R Luksza
Feb 1, 1992·Transplantation·D W Gjertson, P I Terasaki
Jan 1, 1989·Transplantation·R M HoffmannF O Belzer
Jan 1, 1989·Intensive Care Medicine·A Bodenham, G R Park
Nov 1, 1965·Annals of Internal Medicine·V A DiScalaS L Yunis
Apr 1, 1995·British Journal of Anaesthesia·B RiouP Viars
Feb 1, 1993·Critical Care Medicine·B GoldsteinP D Woolf

❮ Previous
Next ❯

Citations

Jan 15, 2004·Indian Journal of Pediatrics·Niranjan Kissoon, Desmond Bohn
May 7, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Joachim Boldt
Feb 26, 2011·Der Anaesthesist·B NohéK Unertl
Aug 8, 2008·Intensive Care Medicine·Frédérique SchortgenUNKNOWN CRYCO Study Group
Jun 18, 2009·Intensive Care Medicine·Christiane Hartog, Konrad Reinhart
Nov 6, 2009·Intensive Care Medicine·Martin Alexander SchickChristian Wunder
Feb 11, 2012·Intensive Care Medicine·Konrad ReinhartUNKNOWN European Society of Intensive Care Medicine
Apr 25, 2012·Intensive Care Medicine·D O Thomas-RueddelC S Hartog
Oct 19, 2010·Journal of Anesthesia·Tomi T NiemiMichiaki Yamakage
Apr 23, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Sean M Bagshaw, Lakhmir S Chawla
Aug 28, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·J-M KorachUNKNOWN French Registry Study Group
Jan 11, 2008·The New England Journal of Medicine·Frank M BrunkhorstUNKNOWN German Competence Network Sepsis (SepNet)
Dec 24, 2004·The New England Journal of Medicine·Kenneth E WoodDouglas B Coursin
Jan 26, 2007·British Journal of Anaesthesia·Y SakrJ-L Vincent
Jan 4, 2012·British Journal of Anaesthesia·D W McKeownJ A Kellum
Aug 16, 2013·British Journal of Anaesthesia·J P Nolan, M G Mythen
Jul 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dominiki EconomidouDimitrios Memmos
Mar 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Frank HokemaUdo Kaisers
Sep 19, 2002·American Journal of Therapeutics·Heather A Hume, Pierre Limoges
Sep 3, 2004·Critical Care Medicine·Steven M HollenbergSergio Zanotti-Cavazzoni
Jul 2, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jean-Michel LietJean-Christophe Rozé
Apr 11, 2008·Critical Care Medicine·Sean M BagshawJohn A Kellum
Apr 11, 2008·Critical Care Medicine·Neesh Pannu, Mitra K Nadim
Sep 25, 2008·Critical Care Medicine·Peter Gosling
Dec 31, 2008·Critical Care Medicine·Christophe HanartPhilippe Van der Linden
Feb 27, 2009·Critical Care Medicine·Jean-Philippe RiouxStéphan Troyanov
Mar 26, 2009·Critical Care Medicine·Ingemar J Davidson
Oct 16, 2009·Critical Care Medicine·Paula DennenRobert Anderson
Sep 12, 2012·Annals of Surgery·Peter GoslingMav Manji
Apr 3, 2013·Transplantation·Tatiana H RechCristiane B Leitão

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.