Effect of hydroxyurea therapy on resting energy expenditure in children with sickle cell disease

Journal of Pediatric Hematology/oncology
E B FungV A Stallings

Abstract

Effects of hydroxyurea therapy on resting energy expenditure (REE) in children with sickle cell disease have not been evaluated. Eight children with sickle cell disease were examined before hydroxyurea therapy and again 6.9 +/- 3.5 months after hydroxyurea initiation. Resting energy expenditure, dietary intake, and growth were assessed. In six children, baseline REE was elevated, and REE decreased an average of 17% with hydroxyurea. This was associated with a significant increase in fetal hemoglobin. These pilot data suggest that hydroxyurea may curtail the hypermetabolic state observed in children with sickle cell disease and may offer a clinically important secondary benefit.

References

Mar 1, 1979·The American Journal of Clinical Nutrition·P V HamillW M Moore
Jan 1, 1992·The American Journal of Pediatric Hematology/oncology·N T GrayR D Horner
Jul 4, 1991·The New England Journal of Medicine·O S PlattT R Kinney
Apr 1, 1987·American Journal of Hematology·J D ReedE P Orringer
Apr 1, 1971·Archives of Disease in Childhood·C G Brook
Jun 1, 1996·The Journal of Pediatrics·J P ScottR J Labotka
Oct 1, 1996·The Journal of Pediatrics·S JayaboseP Visintainer
Apr 8, 1998·Current Opinion in Pediatrics·C HoppeE Vichinsky
Jan 15, 2000·The Journal of Pediatrics·E M BardenV A Stallings
Jan 1, 1993·Nutrition Research Reviews·T J Cole

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Citations

Aug 30, 2008·Annals of Tropical Paediatrics·A-W M Al-SaqladiB J Brabin
Dec 2, 2010·Annals of Tropical Paediatrics·A-W M Al-SaqladiB J Brabin
May 14, 2009·Pediatric Hematology and Oncology·Monica J MitchellJennie Noll
Jul 14, 2009·Annals of Human Biology·Babette Zemel
Jun 23, 2009·Pediatric Blood & Cancer·Melissa RhodesMaciej S Buchowski
Jan 1, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F Mellouli, M Bejaoui
Feb 22, 2017·Journal of Pediatric Hematology/oncology·Andrea ZivotDeepti Raybagkar
Aug 23, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Erica L LiebeltEdward J Stanek
Nov 25, 2004·Hematology·George R BuchananMartin H Steinberg
Nov 7, 2018·BMJ Paediatrics Open·Rachael HallSubarna Chakravorty
Aug 27, 2014·Pediatrics·Sohail RanaUNKNOWN BABY HUG Investigators

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