Effect of hylan G-F 20 in Achilles' tendonitis: an experimental study in rats

Archives of Physical Medicine and Rehabilitation
H TatariSafa Satoğlu

Abstract

To investigate the local effects of hylan G-F 20 on locally administered corticosteroid-induced experimental Achilles' tendonitis. Before-after trial. Institutional practice. Convenience sample of 18 male Wistar white rats (weight range, 322-375 g). After performing Achilles' degeneration with local corticosteroid injections, the rats were divided into 4 groups. The right Achilles' tendon of the rats served as the hylan injection group and the left tendon as the control group, which was injected with saline at 5-day intervals. The tendons and paratenons were excised at the end of 60 or 75 days and evaluated histopathologically and statistically. Histopathologic changes, including staining affinity, nuclear appearance, fibrillar appearance for tendon and thickness, occurrence of fibrosis and edema, capillary changes, and inflammation for paratenon, were assessed according to a semiquantitative scoring system. The Mann-Whitney U test was used for statistical analysis, with a P value of.05 or less considered statistically significant. Semiquantitative scoring of histopathologic changes showed that histologic appearances differed between the hylan and saline groups and between 2 hylan groups. Hylan-injected tendons and paratenons d...Continue Reading

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Citations

Jun 5, 2014·BioMed Research International·Michele AbateVincenzo Salini
Jul 9, 2008·Disability and Rehabilitation·Spencer P LakeLouis J Soslowsky
Feb 17, 2009·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Ibrahim CobanMustafa Fidan
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thijs de WitJohan W van Neck
May 15, 2015·Bioconjugate Chemistry·Christina N M RyanDimitrios I Zeugolis

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