Effect of hyperandrogenism on ovarian function

Reproduction : the Official Journal of the Society for the Study of Fertility
Leandro Martín VelezAlicia Beatriz Motta

Abstract

The objective of this work was to study the ovarian function when follicular development is induced during a hyperandrogenic condition. Female rats were injected with either equine chorionic gonadotropin (eCG group) to induce folliculogenesis or eCG together with DHEA to induce folliculogenesis in a hyperandrogenic condition (eCG+HA group). The control group was injected with vehicle. Ovarian mRNA levels of the peroxisome proliferator-activated receptor gamma (PPARγ) co-activator PGC1α, the PPARγ co-repressor NCoR, the main enzymes involved in the ovarian steroidogenesis (CYP17, 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-HSD, and CYP19A), and cyclooxygenase 2 (COX2) were evaluated only by real-time PCR. COX2 was evaluated by both real-time PCR and western blot. Serum steroid hormones and both the oxidative and inflammatory statuses were also quantified. We found that eCG-induced folliculogenesis induced increased mRNA levels of PGC1α and decreased those of NCoR when compared with controls. In addition, we found an increase in serum estradiol (E2) levels and enhanced mRNA expression of CYP19A. A pro-inflammatory status and a pro-oxidant status were also established. When folliculogenesis was induced in a hyperandrogenic condi...Continue Reading

References

Oct 13, 1995·The Journal of Biological Chemistry·K YuM A Lazar
Feb 28, 2001·Diabetes, Obesity & Metabolism·M J Iuorno, J E Nestler
Mar 30, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·A B MottaM F Gimeno
Aug 24, 2002·Endocrinology·Hyunjung Lim, Sudhansu K Dey
Dec 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thomas M McIntyreGlenn D Prestwich
May 20, 2003·Reproduction in Domestic Animals = Zuchthygiene·M Q Husein, R T Kridli
Feb 7, 2004·Current Diabetes Reports·Emre Seli, Antoni J Duleba
Dec 15, 2004·Journal of Reproductive Immunology·Carolina Griselda LuchettiAlicia B Motta
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeong-Ho KimSeung Joon Baek
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jayeeta Banerjee, Carolyn M Komar
Dec 7, 2006·Annals of the New York Academy of Sciences·Evanthia Diamanti-Kandarakis, Frangiskos Economou
May 15, 2007·Endocrinology·Louise ManneråsElisabet Stener-Victorin
Jul 31, 2007·Reviews in Endocrine & Metabolic Disorders·Daniel A DumesicVasantha Padmanabhan
Mar 20, 2008·Reproductive Biology and Endocrinology : RB&E·John D BrannianMaureen Diggins
Jul 9, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marco Calogero AmatoCarla Giordano
Jul 24, 2010·Nature·Jang Hyun ChoiBruce M Spiegelman
Oct 9, 2012·Cancer Prevention Research·Ofer MargalitRaymond N Dubois

❮ Previous
Next ❯

Citations

Jun 4, 2016·Journal of Developmental Origins of Health and Disease·L PaixãoP M Spritzer
Mar 31, 2018·Journal of Cellular and Molecular Medicine·Rong HuangTao Tao
May 28, 2019·Journal of Developmental Origins of Health and Disease·Giselle Adriana AbruzzeseAlicia Beatriz Motta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.