Effect of hyperbaric oxygen on the ligament healing process in rats

Clinical Orthopaedics and Related Research
Hirotaka MashitoriKoichi Saotome

Abstract

Animal experiments were done to investigate whether administration of hyperbaric oxygen promotes scar tissue formation, increases expression of the Type I procollagen gene, and improves the tensile properties of healing ligament. In 76 Sprague-Dawley rats, a 2-mm segment of the medial collateral ligament was removed. Thirty-eight rats were exposed to hyperbaric oxygen at 2.5 atmospheres absolute for 2 hours 5 days per week (Group H), whereas the remaining rats were exposed to room air (Group C). The animals were sacrificed at 3, 7, 14, and 28 days postoperatively. In situ hybridization histochemistry was done to examine the Type I procollagen gene expression in healing ligaments in 40 rats, whereas a tensile failure test was done in the remaining rats. The amount of scar tissue was greater in Group H than in Group C. Type I procollagen gene expression at 7 or 14 days was significantly greater in Group H than in Group C. The ultimate load and stiffness in Group H were significantly greater than in Group C at 14 days. Administration of hyperbaric oxygen promotes scar tissue formation and increases Type I procollagen gene expression in healing ligaments. These effects are associated with the improvement of their tensile properties.

References

Sep 1, 1991·Journal of Applied Physiology·J M ClarkM Unger
Jan 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D ChimichR Bray
May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M E WiigK E Arfors
Jan 1, 1990·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E BarthE Berg
Jul 1, 1990·The American Journal of Sports Medicine·P Burroughs, L E Dahners
Jan 1, 1986·Journal of Biomechanics·S L WooW H Akeson
May 1, 1986·The American Journal of Sports Medicine·K E DeHaven, D M Lintner
Feb 1, 1994·Burns : Journal of the International Society for Burn Injuries·P Cianci, R Sato
Oct 1, 1996·Sports Medicine·J Staples, D Clement
Apr 1, 1997·International Journal of Oral and Maxillofacial Surgery·P C TompachJ L Stoll
Sep 26, 1997·The American Journal of Sports Medicine·C N BorromeoA A Bove
Jun 9, 1998·The American Journal of Sports Medicine·T M BestR Vanderby
Aug 5, 1998·The American Journal of Sports Medicine·K A HildebrandC C Schmidt
Apr 2, 1999·Clinical Orthopaedics and Related Research·P C HornM D Fortino
Feb 9, 2000·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·H SakaiH Kurosawa
Nov 22, 2000·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·S Babul
Feb 24, 2001·Medicine and Science in Sports and Exercise·B C HarrisonW C Byrnes
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H SakaiK Saotome
Mar 29, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yoshimasa IshiiYutaka Miyanaga
Nov 1, 1995·The Physician and Sportsmedicine·Carol Potera

❮ Previous
Next ❯

Citations

Sep 6, 2005·Sports Medicine·Yoshimasa IshiiMitsuo Ochi
Apr 1, 2011·Therapeutic Advances in Musculoskeletal Disease·Pedro BarataFrankim Marques
Dec 27, 2019·Medicine and Science in Sports and Exercise·Navid MoghadamRenie Guilliod

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.