PMID: 9537659Apr 16, 1998Paper

Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats

Surgical Neurology
M KrakovskyAvraham Mayevsky

Abstract

Hyperbaric oxygenation (HBO) has been considered for many years for the treatment of severe brain ischemia. However, its efficacy has not been proven. The aim of this study was to shed light on this question. Acute global cerebral ischemia was induced in 18 rats using the four-vessel occlusion model. Regional cerebral blood flow (CBF) was determined by laser-Doppler flowmetry using a flexible 1 mm fiberoptic probe. Two stainless steel screws were used to measure the spontaneous electrical activity from the contralateral hemisphere. After ischemia monitored by laser-Doppler flowmetry and ECoG, the animals were divided into two groups: (1) control animals that breathed air at atmospheric pressure and (2) rats exposed to HBO at three atmospheres absolute pressure (ATA) for 1 hour. Survival time and rate were recorded for both groups of animals for 14 days. The survival rate in the study group was significantly higher (45%) than in the control group (0%). In the animals that did not survive the 14-day period, those exposed to HBO survived longer than the control animals (59.8+/-9.1 hour versus 17.9+/-2.7 hours, p < 0.05). This investigation demonstrates that HBO administered after global cerebral ischemia can increase survival in a...Continue Reading

Citations

Dec 4, 2012·Journal of Clinical Monitoring and Computing·Avraham Mayevsky, Efrat Barbiro-Michaely
Sep 3, 2003·Biochemical and Biophysical Research Communications·Changman ZhouJohn H Zhang
May 5, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·John H ZhangAustin Colohan
Apr 9, 2005·Critical Care Medicine·Hsin-Mao TsaiKo-Chi Niu
Aug 10, 2006·Clinical and Experimental Pharmacology & Physiology·Sheng-Hsien ChenMao-Tsun Lin
Apr 19, 2007·Neurological Research·Edwin M Nemoto, Kerstin Betterman
Apr 19, 2007·Neurological Research·Aneesh B Singhal
Jan 27, 2011·Molecular Neurodegeneration·Trent M WoodruffThiruma V Arumugam
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Aneesh B Singhal
Apr 9, 2010·Basic & Clinical Pharmacology & Toxicology·Ilan YoungsterMatitiahu Berkovitch
Nov 22, 2000·Experimental Neurology·C F ChangC V Borlongan
Oct 19, 2005·Cerebrovascular Diseases·Ann K HelmsMichel T Torbey
Apr 5, 2003·Stroke; a Journal of Cerebral Circulation·Robert E RosenthalGary Fiskum
Aug 9, 2003·Intensive Care Medicine·Yalçin KocaoğullarDamirez Fossett
Jul 21, 2001·Annals of the New York Academy of Sciences·R N Auer
Feb 22, 2017·Medical Gas Research·Sheng-Li HuGuo-Hua Xi
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A E BadrJ H Zhang

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