Effect of hyperbaric oxygen treatment on immunological parameters in multiple sclerosis

Acta Neurologica Scandinavica
H NylandC Hordnes

Abstract

Hyperbaric oxygen (HBO) treatment has been reported to cause amelioration of clinical symptoms in patients with multiple sclerosis (MS). We have treated 10 MS patients with hyperbaric oxygen (100% O2 at 2 atmospheres absolute for 90 min daily for a total of 20 exposures), and performed immunological studies on peripheral blood and cerebrospinal fluid (CSF). After treatment there was a significant increase in total and helper T lymphocyte counts in peripheral blood, as well as an increase in both E, Fc gamma and C3b receptor-bearing lymphocytes. The responses to the mitogens PHA, con A and PWM were unchanged. Granulocytes showed an increased proportion of Fc gamma receptor and C3b receptor positive cells after treatment. The O2 consumption of granulocytes also increased, but phagocytosis, as measured by chemiluminescence, was unchanged. Serum IgA levels were slightly increased, while IgG and IgM concentrations remained unchanged after treatment. Cerebrospinal fluid cell counts, protein and IgG concentrations, as well as IgG indexes remained unchanged.

References

Jan 1, 1976·Immunological Communications·C M Steel, G H Creasey
Jan 1, 1976·Scandinavian Journal of Immunology·R Matre, O Tönder
Feb 8, 1986·British Medical Journal·C M WilesA V Swan
Nov 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·M P BarnesD A Shaw
Jun 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·J NeimanD J Perrins
Jan 1, 1973·International Archives of Allergy and Applied Immunology·T HallbergR R Coombs
Jun 1, 1984·Journal of Leukocyte Biology·B HanebergC O Solberg
Jan 27, 1983·The New England Journal of Medicine·B H FischerT Reich
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·J GletteC O Solberg
Jan 1, 1982·Scandinavian Journal of Infectious Diseases·C O SolbergJ Glette

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