PMID: 6103495Apr 1, 1980Paper

Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog

Metabolism: Clinical and Experimental
G I ShulmanAlan D Cherrington

Abstract

In the face of fixed basal levels of insulin (9 microunits/ml) and glucagon (63 pg/ml) maintained by the infusion of somatostatin and replacement amounts of the two pancreatic hormones, the mean arterial plasma glucose concentration was elevated from 102 to 217 mg/dl by continuous glucose infusion. Hyperglycemia resulted in a significant decrease in the arterial blood glycerol (35%) and plasma free fatty acid concentrations (46%). The drop in the blood glycerol level was paralleled by a decline in hepatic glycerol uptake indicating that hyperglycemia did not alter the fractional extraction of glycerol by the liver. These results support the view that glucose has a direct antilipolytic effect in vivo.

References

Nov 1, 1977·Clinical Science and Molecular Medicine·L SestoftO S Schaffalitzky de Muckadell
Dec 1, 1976·The Journal of Clinical Investigation·A D CherringtonW W Lacy
Oct 1, 1969·Archives internationales de physiologie et de biochimie·F Camu
Oct 1, 1972·Canadian Journal of Physiology and Pharmacology·A CherringtonN Kovacevic
Jun 1, 1969·The American Journal of the Medical Sciences·E Aguilar-ParadaR H Unger
Oct 1, 1971·Metabolism: Clinical and Experimental·M VranicB J Lin
Jul 1, 1970·Analytical Biochemistry·R J Ho
Jan 1, 1966·Canadian Journal of Physiology and Pharmacology·J Campbell, G R Green
Jan 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·R S GORDON, A CHERKES
Feb 1, 1960·The Journal of Clinical Investigation·M S RABEN, C H HOLLENBERG

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Citations

Nov 1, 1982·Pflügers Archiv : European journal of physiology·Y MinaireG Dallevet
Jan 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C F TosoL M Linares
Aug 17, 2011·Diabetes, Obesity & Metabolism·C J RamnananA D Cherrington
May 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·R SkowronskiG M Reaven
Apr 1, 1985·The Journal of Clinical Investigation·S LilliojaB V Howard
Feb 1, 1987·The Journal of Clinical Investigation·S Del PratoR A DeFronzo
May 1, 1988·The Journal of Clinical Investigation·H MiyoshiR R Wolfe
Jan 1, 1992·The Journal of Clinical Investigation·N NurjhanJ Gerich
May 29, 2002·Diabetes·Shosuke SatakeAlan D Cherrington
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E ShmueliC O Record
Jan 1, 1987·Diabetes/metabolism Reviews·A D CherringtonP E Williams
Feb 1, 1988·Diabetes/metabolism Reviews·R T FrizzellA D Cherrington
Jul 1, 1982·Clinics in Endocrinology and Metabolism·D G Johnston, K G Alberti
Jul 1, 1983·Clinics in Endocrinology and Metabolism·J M Miles, J E Gerich
Sep 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·R C TaoF Benjamin
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S PetridesG Strohmeyer
Mar 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jaime M GrubertOwen P McGuinness
May 15, 2007·The Journal of Physiology·Patrick T FuegerDavid H Wasserman
Mar 10, 1999·The American Journal of Physiology·L S SidossisR R Wolfe
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·C C ConnollyJ L Chiasson
Jun 1, 1985·The American Journal of Physiology·R R WolfeM J Durkot
Oct 1, 1987·The American Journal of Physiology·G K HendrickA D Cherrington
Nov 14, 1997·The American Journal of Physiology·O P McGuinnessA D Cherrington
Aug 1, 1983·The American Journal of Physiology·R W StevensonK G Alberti
Feb 1, 1987·The American Journal of Physiology·R R Wolfe, E J Peters
Jul 1, 1986·Metabolism: Clinical and Experimental·J P RiouR Mornex
Jun 1, 1986·Metabolism: Clinical and Experimental·S LilliojaB V Howard
Oct 1, 1991·Metabolism: Clinical and Experimental·K E SteinerA D Cherrington
Apr 1, 1984·Metabolism: Clinical and Experimental·R P Brockman

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