PMID: 2493119Jan 1, 1989Paper

Effect of hyperosmotic mannitol on magnetic resonance relaxation parameters in reperfused canine myocardial infarction

Magnetic Resonance Imaging
D D MillerR D Okada

Abstract

To determine how administration of a hyperosmotic agent alters regional nuclear magnetic resonance (NMR) relaxation parameters and imaging characteristics in ischemic-reperfused myocardium, 7 dogs were infused with mannitol for 15 minutes before and after the release of a 3 hour left anterior descending coronary artery (LAD) occlusion. Nine control animals received normal saline during the 3 hour occlusion and 1 hour reperfusion periods. Normal posterior left ventricular (LV) wall and the ischemic anterior LV wall (risk area) myocardium was sampled for calculation of segmental microsphere myocardial blood flow, % tissue water content, NMR relaxation times (T1, T2) and myocyte ultrastructure using electron microscopy. Mean infarct T1 values were 14% greater than normal segments in saline-treated controls, but only 5% greater after mannitol. The difference in tissue water content between infarcted and normal segments was 4% in saline-treated (83 vs. 79%) compared to 2% in mannitol-treated dogs (79 vs. 77%). T1, T2 and % water content of control infarct segments were greater than treated infarcts (p less than 0.01). T1 and T2 rose as occlusion flow fell below 0.5 ml/min/g in control hearts but did not rise until flows were reduced...Continue Reading

References

Aug 1, 1987·Journal of the American College of Cardiology·R C CanbyG M Pohost
Apr 1, 1986·Journal of the American College of Cardiology·P W PflugfelderS E Carroll

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Citations

Sep 17, 2011·JACC. Cardiovascular Imaging·Matthias G FriedrichRaymond J Kim
Apr 1, 1991·American Heart Journal·E E van der WallA V Bruschke
Dec 25, 2013·Journal of the American Heart Association·W Benjamin WinceU Joseph Schoepf
Nov 1, 1995·Circulation·E E van der WallA V Bruschke

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