PMID: 2112127Apr 1, 1990Paper

Effect of hyperoxemia and ritanserin on skeletal muscle microflow

Journal of Applied Physiology
P A ThorborgD H Lewis

Abstract

Serotonin2 (5-HT2) receptor antagonists (ketanserin, ritanserin) can normalize a hyperoxemia-induced disturbance in skeletal muscle oxygenation, presumably by local microflow changes. The purpose of this study was to develop equipment for local hydrogen clearance measurements with a modified eight-channel platinum electrode to assess changes in local skeletal muscle capillary blood flow induced by hyperoxemia and ritanserin (0.035 mg/kg) during hyperoxemia. Laser-Doppler flowmetry was used for regional microflow measurements. Two groups of six anesthetized and artificially ventilated rabbits were studied: group I with normoxemia and hyperoxemia [arterial PO2 (PaO2) 48 kPa; 360 Torr] and group II before and after ritanserin with hyperoxemia (PaO2 46 kPa; 345 Torr). In group I, hyperoxemia induced a mean local hydrogen clearance decrease of 22% while laser-Doppler flowmetry signal decreased 31%. In group II, ritanserin induced a 125% mean local hydrogen clearance increase compared with hyperoxemia (or 37% compared with group I normoxemia); laser-Doppler flowmetry signal increased 30%. The sum distribution of local hydrogen clearances shifted to the left during hyperoxemia and to the right after ritanserin. The conclusion from thi...Continue Reading

Citations

Apr 27, 1999·British Journal of Pharmacology·E Raczka, A Quintana
Aug 19, 2004·Acta Anaesthesiologica Scandinavica·G I KemmingO P Habler
Aug 1, 2007·Asian Cardiovascular & Thoracic Annals·Fevzi ToramanCem Alhan
Mar 11, 1999·Acta Physiologica Scandinavica·F SjöbergC Eintrei
Jun 22, 2016·The Journal of Physiology·William F Jackson
Apr 1, 1996·The American Journal of Physiology·J M NewmanM G Clark

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